多糖类成分抗胰腺癌作用机制的研究进展

Research progress on the effect mechanism of polysaccharides against pancreatic cancer

多糖是公认的免疫调节剂,已被证实对多种癌细胞具有抑制作用,具有开发为抗癌药物的潜力。胰腺癌作为病死率最高的癌症之一,长期采用化疗药物治疗,易产生免疫缺陷、疲劳、神经系统病变等多种副作用。本文总结了国内外多糖类成分抗胰腺癌的研究现状,梳理出多糖类成分可以通过多靶点的作用方式,调控核因子κB、Hippo-转录共激活因子相关蛋白、整合素等相关信号通路,诱导癌细胞凋亡、自噬,抑制癌细胞增殖、迁移与侵袭,调控癌细胞周期,从而发挥抗胰腺癌的作用。

Polysaccharide is a recognized immunomodulator that has been shown to have inhibitory effects on a variety of cancer cells and has the potential to be developed as an anti-cancer drug. Pancreatic cancer, one of the cancers with the highest mortality rate, is treated with long-term chemotherapeutic drugs and is prone to a variety of side effects such as immune deficiency, fatigue, and neurological lesions. The polysaccharide anti-pancreatic cancer research landscape both domestically and internationally is summarized in this publication. By regulating nuclear factor-κB, Hippo-Yes-associated protein, integrin and other signaling pathways, polysaccharide components play an anti-pancreatic cancer role by multi-target ways, such as inducing apoptosis and autophagy, inhibiting proliferation, migration and invasion of cancer cells, and regulating the cancer cell cycle.