二甲双胍联合度拉糖肽治疗2型糖尿病的临床效果探讨

Clinical Effect of Metformin Combined with Dura-glycopeptide in the Treatment of Diabetes Mellitus Type 2

目的 探究度拉糖肽应用于2型糖尿病患者治疗中的临床效果探讨。方法 选取2021年5月—2022年5月期间鄂尔多斯市中心医院收治并确诊为2型糖尿病患者112例为研究对象,将其依照随机数表法分为对照组与研究组,每组56例。对照组使用二甲双胍联合格列美脲方法,研究组采用二甲双胍联合度拉糖肽治疗方法,比较治疗后两组患者的生活质量、不良反应发生率、空腹血糖(FPG)水平、餐后2 h血糖(2 hPG)水平、并发症发生率和治疗有效率。结果 研究组生活质量、治疗有效率情况均优于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05);研究组FPG、2 hPG水平低于对照组,差异有统计学意义(P<0.05);研究组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论 在临床上2型糖尿病患者治疗中应用度拉糖肽方法具有良好的治疗效果。

Objective To exploring the clinical effect of dulaglutide in the treatment of diabetes mellitus type 2 patients.Methods 112 patients with diabetes mellitus type 2 who were admitted to Ordos Central Hospital from May2021 to May 2022 were selected as research subjects. They were divided into control group and study group according to random number table method, 56 cases in each group. The control group was treated with metformin combined with glimepiride and the study group was treated with metformin combined with Dura-glycopeptide. The quality of life, incidence of adverse effects, fasting blood glucose(FPG) level, 2 h postprandial blood glucose(2 hPG) level, complication rate and treatment efficiency were compared between the two groups after treatment.Results The quality of life and the effective rate of treatment in the study group were better than those in the control group, and the difference was statistically significant(P<0.05);the incidence of adverse reactions in the study was lower than that in the control group, and the difference was statistically significant(P<0.05);the levels of FPG and 2 hPG in the study group were lower than those in the control group, and the difference was statistically significant(P<0.05);the incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant(P<0.05).Conclusion The application of Dura-glycopeptide method in the clinical treatment of type 2 diabetic patients has a good therapeutic effect.