GLP-1受体激动剂联合门冬胰岛素30对2型糖尿病患者控糖效果及体质量的影响研究

Study on the Effect of GLP-1 Receptor Agonist Combined with Menadione Insulin 30 on Glucose Control Effect and Body Mass in Type 2 Diabetic Patients

目的探讨对2型糖尿病患者采用胰高血糖素样肽(glucagon-like peptide-1,GLP-1)受体激动剂+门冬胰岛素30完成治疗后获得的控糖效果及对体质量产生的影响。方法选取南京市江宁医院内分泌科2018年1月—2021年4月收治的80例2型糖尿病患者为研究对象,随机分为常规组(采用门冬胰岛素30治疗)和研究组(采用GLP-1受体激动剂+门冬胰岛素30治疗),各40例。比较两组患者控糖效果、脂质生化指标、控糖指标及BMI水平、低血糖反应发生率。结果研究组治疗总有效率(97.50%)高于常规组(75.00%),差异有统计学意义(P<0.05);治疗后,研究组TC、TG、LDL-C水平、控糖指标及BMI水平均低于常规组,差异有统计学意义(P<0.05);研究组低血糖反应发生率(5.00%)低于常规组(30.00%),差异有统计学意义(P<0.05),但两组均未出现严重低血糖事件及严重不良反应现象。结论有效应用GLP-1受体激动剂+门冬胰岛素30,可显著提高2型糖尿病患者控糖效果,有效改善脂质生化指标、控糖指标及BMI水平,降低低血糖反应发生率,改善患者预后水平。

Objective To investigate the effect of glucagon-like peptide-1(GLP-1)receptor agonist combined with menadione insulin 30 on glucose control and body mass in patients with type 2 diabetes mellitus.Methods Eighty patients with type 2 diabetes mellitus admitted to the Department of Endocrinology,Jiangning Hospital of Nanjing from January 2018 to April 2021 were selected for the study.The patients were randomly divided into a conventional group(treated with menadione insulin 30)and a study group(treated with GLP-1 receptor agonist+menadione insulin 30),40 cases in each group.The glucose control effect,lipid biochemical index,glucose control index and BMI level,and the incidence of hypoglycemic reaction were compared between the two groups.Results The total effective rate of treatment in the study group(97.50%)was higher than that in the conventional group(75.00%),and the difference was statistically significant(P<0.05).After treatment,the TC,TG,LDL-C levels,glucose control index and BMI levels of the study group were lower than those of the conventional group,and the difference was statistically significant(P<0.05).The incidence of hypoglycemic reactions in the study group(5.00%)was lower than that in the conventional group(30.00%),and the difference was statistically significant(P<0.05),but no serious hypoglycemic events and serious adverse reactions were observed in both groups.Conclusion The effective application of GLP-1 agonist+menadione insulin 30 can significantly improve the effect of glucose control in patients with type 2 diabetes,effectively improve the lipid biochemical index,glucose control index and BMI level,reduce the incidence of hypoglycemic reactions,and improve the prognosis of patients.