清肺解毒汤治疗宫内感染所致新生儿肺损伤的疗效及对患儿血清PAF和SP-A水平的影响

Efficacy of Qingfei Jiedu Decoction in the treatment of intrauterine infection induced neonatal pulmonary injury and the influence on serum PAF and SP-A levels of children

目的探讨清肺解毒汤治疗宫内感染所致新生儿肺损伤的疗效,并分析其对患儿血清血小板活化因子(PAF)、肺表面活性蛋白A(SP-A)水平的影响。方法选取121例宫内感染所致新生儿肺损伤患儿,将其随机分为综合组61例和西医组60例。西医组采用常规西医治疗,综合组在常规西医治疗的基础上给予清肺解毒汤治疗。比较两组患儿治疗前后的肺顺应性、氧合指数、血清PAF和SP-A水平,以及临床疗效、病情恢复情况、并发症及不良反应的发生率。结果治疗10 d后,两组患儿的肺顺应性、氧合指数、血清SP-A水平均升高,而血清PAF水平降低,且综合组的上述指标均优于西医组(均P<0.05)。综合组的总有效率高于西医组,纠正低氧血症所需时间、恢复正常呼吸所需时间、辅助通气时间、住院时间均短于西医组(均P<0.05)。两组的并发症发生率差异无统计学意义(P>0.05)。两组患儿均未发生明显不良反应。结论在常规西医治疗的基础上加用清肺解毒汤可更有效地改善宫内感染所致新生儿肺损伤患儿的肺功能、血清PAF及SP-A水平,提高治疗效果,促进患儿的病情恢复,且安全性较好。

Objective To explore the efficacy of Qingfei Jiedu Decoction on neonatal pulmonary injury induced by intrauterine infection,and to analyze its influence on serum platelet activating factor(PAF)and pulmonary surfactant protein A(SP-A)levels.Methods A total of 121 children with neonatal pulmonary injury were selected,and they were randomly divided into comprehensive group(61 cases)or Western Medicine group(60 cases).The Western Medicine group was treated with routine Western Medicine,based on which the comprehensive group was treated with Qingfei Jiedu Decoction.The pulmonary compliance,oxygenation index,serum PAF and SP-A levels before and after treatment,and the clinical efficacy,recovery conditions,as well as the incidence rate of complications and adverse reactions were compared between the two groups.Results After 10 days of treatment,the pulmonary compliance,oxygenation index,and serum SP-A level of the two groups were increased,whereas the serum PAF level declined,and the aforementioned indices of the comprehensive group was superior to those of the Western Medicine group(all P<0.05).The comprehensive group exhibited a higher total effective rate as compared with the Western Medicine group,and shorter time to correct hypoxemia,recover normal breathing,a shorter assisted ventilation time,and a shorter length of hospital stay as compared with the Western Medicine group(all P<0.05).There was no statistically significant difference in the incidence rate of complications between the two groups(P>0.05).No significant adverse reactions of both groups occurred.Conclusion Based on routine Western Medicine therapy,additionally employing Qingfei Jiedu Decoction can effectively ameliorate pulmonary function,serum PAF and SP-A levels in children with neonatal pulmonary injury induced by intrauterine infection,improve their therapeutic effect,and promote the recovery of disease in children,exerting a relatively good safety.