聚焦MRI对多发性硬化的研究进展

Research Development in Patients with Multiple Sclerosis by Focus on MRI

多发性硬化(MS)是中枢神经系统最常见的炎性脱髓鞘免疫性疾病,其临床表现缺乏特异性,也缺乏诊断的金标准。常规MRI不仅可显示明显的脱髓鞘病灶,不断发展的多种MRI技术还能评估MS患者大脑灰白质的隐匿性损害、微结构损伤以及脑内铁的沉积,对揭示MS患者的病理演变过程、转归、治疗后的监测和预后判断都具有不可替代的作用。本文对近年来MRI技术在MS中的应用及其临床价值进行综述。

Multiple sclerosis(MS) is an autoimmune inflammatory demyelinating disease of the central nervous system whose clinical manifestations and diagnostic criteria are non-specific and absence of golden criteria when diagnosing. Magnetic resonance imaging(MRI) can not only observe the focal lesions of demyelination, but also evaluate microstructural damages and iron deposition in the white/gray matter in MS patients by applying various developing sequences. MRIs play an irreplaceable role in revealing pathological evolution, prognosis and monitoring after treatment of MS patients. This paper reviewed the clinical value and application of MRIs for the MS patients in recent years.