摘要
In a recent study published in Nature,1Zhang et al.reported that activated B cells produced and released the principal inhibitory neurotransmitter y-aminobutyric acid(GABA).The GABA secretion was demonstrated to inhibit cancer immunity by suppressing cytotoxic T cells and macrophages.The study revealed a new immune regulation mechanism of B cells,which suggests a new direction to understand cancer immunity and develop immunotherapeutics.
基金
Y.Shi receives funding support from the European Research Council(ERC Starting Grant,101040996)
the German Research Foundation(DFG,SH 1223/1-1)
the Excellence Strategy of the Federal Government and the Lander(Project(DE-82)EXS-SF-OPSF580).
