摘要
In a recent study published in Nature,Zuin et al.elucidate the molecular mechanisms of how enhancer positioning and strength affect gene expression levels.'Cell-type-specific transcription factors(TFs)and ubiquitously expressed cofactors regulate the complex network of eukar-yotic gene transcription in an exquisitely specific and sensitive manner.The DNA elements bound by TFs are called enhancers and can be located close to the transcription start site(TSS)or far away.
