基于生物信息学分析SLC2A1在胰腺癌中的表达及临床意义

Bioinformatics analysis of SLC2A1 expression in pancreatic cancer and its clinical significance

目的探讨胰腺癌中溶质载体家族2促进葡萄糖转运蛋白成员1(Solute carrier family 2 facilitated glucose transporter member 1,SLC2A1)的表达及临床意义。方法检索CEPIA数据库中SLC2A1表达量,分析胰腺癌和正常对照组SLC2A1的差异。从TCGA数据库中下载胰腺癌SLC2A1 RNA数据及临床病理资料,利用R和SPSS软件分析SLC2A1表达与临床病理特征及预后的关系。Kaplan-Meier plotter和CEPIA数据库分析SLC2A1表达与生存时间的关系。结果CEPIA数据库显示胰腺癌组织中SLC2A1的表达量明显高于正常对照组(P<0.05)。SLC2A1高表达与胰腺癌浸润深度显著相关(P=0.002),而与年龄、性别、病理分级、淋巴结转移、远处转移、肿瘤分期的相关性均无统计学意义(P均>0.05)。Kaplan-Meier plotter结果显示SLC2A1低表达组的总生存期和无复发生存期均较高表达组明显延长(P均<0.05)。CEPIA显示SLC2A1低表达组的总生存期和无病生存期均较高表达组明显延长(P均<0.05)。COX多因素回归分析提示SLC2A1是胰腺癌患者总生存期的独立危险因素。结论SLC2A1在胰腺癌组织中高表达,与胰腺癌浸润深度、总生存期、无复发生存期、无病生存期显著相关,而且是胰腺癌患者总生存期的独立危险因素。

Objective To investigate the expression and clinical significance of Solute carrier family 2 facilitated glucose transporter member 1(SLC2A1)in patients with pancreatic cancer.Methods Information of SLC2A1 in CEPIA database was searched to analyze the expression of SLC2A1 in pancreatic cancer and normal control group.The SLC2A1 RNA data and clinicopathological data of pancreatic cancer were downloaded from the TCGA database.The relationship between SLC2A1 expression and clinicopathological features and prognosis was analyzed by R and SPSS software.The correlation between SLC2A1 expression and survival time was analyzed in Kaplan Meier plotter and GEPIA database.Results The expression of SLC2A1 in pancreatic cancer tissues was significantly higher than that in the normal control group in CEPIA database(P<0.05).The high expression of SLC2A1 was significantly correlated with the depth of invasion(P=0.002),but not correlated with age,gender,pathological grade,lymph node metastasis,distant metastasis and tumor stage(all P>0.05).The results of Kaplan Meier plotter showed that the overall survival time and recurrence free survival time of patients in the group of low SLC2A1 expression were significantly longer and that in the group of high SLC2A1 expression,respectively(both P<0.05).The results of CEPIA showed that the overall survival time and disease free survival time of patients in the group of low SLC2A1 expression were significantly longer and that in the group of high SLC2A1 expression,respectively(both P<0.05).COX multivariate regression analysis indicated that SLC2A1 was an independent risk factor for overall survival time in patients with pancreatic cancer.Conclusions The high expression of SLC2A1 in pancreatic cancer is significantly associated with invasion depth,overall survival time,disease free survival time,and recurrence free survival time.And SLC2A1 is also an independent risk factor for overall survival time in patients with pancreatic cancer.