基因变异对儿童肥胖干预效果作用的研究进展

Research progress on genetic variants’ effects on childhood obesity interventions

近几十年来,儿童肥胖率持续上升,健康危害严重,已成为重要公共卫生问题。生活方式干预是预防儿童肥胖的有效手段。然而,干预效果在不同个体间有一定差异,可能由遗传因素导致。系统阐释FTO、MC4R和其他基因变异对儿童肥胖干预效果作用的研究进展,总结目前研究的局限性及未来研究方向,为制定基于遗传背景的儿童肥胖精准干预策略提供依据。

In recent decades, the prevalence of childhood obesity has increased at a alarming rate. The health hazards of childhood obesity are substantial, which has become an important public health problem. Lifestyle intervention is an effective means to prevent childhood obesity. However, individuals varied in their response to the intervention program, which may be associated with genetic factors. This paper systematically reviews the research progress of the effects of FTO, MC4R and other genetic variants on childhood obesity interventions, summarizes the limitations of current research and sheds light on the future research, so as to provide scientific evidence for individualized childhood obesity interventions based on genetic backgrounds.