有机小分子催化不对称Michael加成反应研究进展

Progress in asymmetric Michael addition reactions catalyzed by small organic molecules

Michael加成是一种高效形成碳-碳的有机反应,不对称Michael加成反应是合成具有手性中心化合物的重要方法。近年来,有机小分子催化剂促进的不对称Michael加成反应得到了快速的发展。按照种类的不同,有机小分子催化剂主要分为胺类有机小分子催化剂、吡咯烷类有机小分子催化剂、硫脲类有机小分子催化剂以及膦酸类有机催化剂等。综述了不对称Michael加成反应研究进展,期望对不对称催化反应研究起到参考和借鉴作用。

Michael addition reaction is an efficient carbon-carbon bond formation reaction in organic chemistry.Asymmetric Michael addition is an important method to synthesize chiral compounds.In recent years,the research on asymmetric Michael addition reaction catalyzed by small organic molecules have been developed rapidly.According to the different types of small organic molecule catalysts,they were mainly divided into amine organic molecule catalysts,pyrrolidine organic molecule catalysts,thiourea organic molecule catalysts,phosphonic acid organic catalysts,etc.The research progress of asymmetric Michael addition reaction was reviewed,which was expected to be a reference for the study of asymmetric catalytic reaction.