基于数据挖掘的藏医治疗隆病的用药规律探索与分析

Exploration and Analysis of Long Disease(隆病)Treatment of Tibetan Medicine Based on Data Mining

目的:以《四部医典》《月王药诊》《藏药方剂宝库》等藏医书籍为基础,对藏医治疗隆病的方剂进行统计分析,以探讨其用药规律。方法:筛选相关文献中治疗隆病的方剂并进行标准化。使用Clementine 12.0进行关联规则分析;使用SPSS 20.0统计软件进行聚类分析;利用Gephi软件构建药物关联网络。结果:共收集方剂174首,涉及药物259味,药味多为甘、苦、辛,药性多为热、寒、平、润,核心药物为肉豆蔻、干姜、丁香、荜茇等,常用药物组合有荜茇-胡椒、肉豆蔻-丁香、阿魏-紫硇砂等。结论:藏医多用辛、甘、热、润的药物对治隆病,以平衡水土、综合调隆、协调三因为用药特点。核心药物肉豆蔻能与广酸枣、沉香等组合作用于胃肠、心脏、神经等多个器官和组织,次要核心药物干姜、荜茇等可调节胃肠功能促进疾病恢复。

Objective:Based on The Four Medical Tantras,Yuewang Yaozhen,The Treasure House of Tibetan Medicine Prescriptions and so on,statistical analysis is conducted on the prescriptions of Tibetan medicine for the treatment of Long Disease(The pathogenic factor is"Long"disorder,Tibetan medicine believes that"Long"constitutes one of the three major elements of life)to explore the regularity of Tibetan medicine for treating Long diseases.Methods:The prescriptions for Longbing disease in relevant literatures were screened and standardized.Use Clementine 12.0 to analyze association rules;SPSS 20.0 statistical software was used for cluster analysis;Use Gephi software to construct drug association network.Results:174 prescriptions are collected,involving 259 medicines.The flavors of medicinal are mostly sweet,bitter,and pungent,the properties are mostly hot,cold,neutral and moist.The core medicines are Roudoukou(Myristicae semen),Ganjiang(Zingiberis rhizoma),Dingxiang(Caryophylli flos),Bibo(Piperis longi fructus).Common medicine combinations include Bibo(Piperis longi Fructus)-Hujiao(Piperis fructus),Roudoukou(Myristicae semen)-Dingxiang(Caryophylli flos),Awei(Ferulae resina)-Zixinsha(Red halite),and so on.Conclusions:Through data mining,Tibetan medicine mostly uses the flavors of pungent,sweet,hot and moist drugs for the treatment of Long Disease,and with characteristics of balancing water and earth elements in body,comprehensive regulation of Long element and coordination of the three causes.Roudoukou(Myristicae semen),the core drug,can act on stomach,heart,nerves and other organs and tissues in combination with Guangsuanzao(Choerospondiatis fructus)and Chenxiang(Aquilariae lignum resinatum).Secondary core drugs Ganjiang(Zingiberis rhizoma)and Bibo(Piperis longi fructus)can regulate gastrointestinal function and promote disease recovery.