阿加曲班治疗急性缺血性脑卒中的临床效果分析

Clinical Effect Analysis of Argatroban in the Treatment of Acute Ischemic Stroke

目的分析阿加曲班治疗急性缺血性脑卒中的临床效果。方法选取2018年5月—2021年12月丰县中医医院收治的急性缺血性脑卒中患者58例,以随机摸球法分为两组,对照组(29例)予以阿替普酶治疗,观察组(29例)在对照组基础上联合阿加曲班治疗,对比两组患者神经功能损伤评分、凝血指标、炎症因子以及生活质量评分。结果治疗7、14 d后,观察组NIHSS评分为(9.15±0.78)分、(8.15±0.70)分,低于对照组的(10.27±0.80)分、(9.69±0.75)分,差异有统计学意义(t=5.398、8.084,P<0.05)。治疗后,观察组血小板计数为(241.19±12.54)×10^(9)/L,高于对照组的(218.64±10.40)×10^(9)/L,差异有统计学意义(t=7.454,P<0.05);两组部分凝血酶原时间相比,差异无统计学意义(P>0.05)。治疗后,观察组TNF-α、IL-6、IL-8水平为(50.18±2.46)、(1.43±0.29)、(181.34±16.23)ng/L,低于对照组的(65.81±3.22)、(2.10±0.31)、(214.34±19.40)ng/L,差异有统计学意义(t=20.772、8.500、7.026,P<0.05)。治疗后,观察组患者生活质量评分显著高于对照组,差异有统计学意义(t=2.960、7.173,P<0.05)。结论急性缺血性脑卒中患者采用阿加曲班治疗时可有效改善神经功能损伤,控制凝血指标,降低炎症指标,并提升其生活质量。

Objective To analyze the clinical effect of argatroban in the treatment of acute ischemic stroke.Methods A total of 58 patients with acute ischemic stroke admitted to Fengxian County Traditional Chinese Medicine Hospital from May 2018 to December 2021 were selected and divided into two groups by random ball touching method.The control group(29 cases)was treated with alteplase,and the observation group(29 cases)was treated with argatroban on the basis of the control group.The neurological impairment scores,coagulation indexes,inflammatory factors and quality of life scores were compared between the two groups of patients.Results After 7 d and 14 d of treatment,the NIHSS scores of the observation group were(9.15±0.78)points and(8.15±0.70)points,which were lower than those of the control group(10.27±0.80)points and(9.69±0.75)points,and the differences were statistically significant(t=5.398,8.084,P<0.05).After treatment,the platelet count the observation group was(241.19±12.54)×10^(9)/L,which was higher than that of the control group(218.64±10.40)×10^(9)/L,and the difference was statistically significant(t=7.454,P<0.05).There was no statistically significant difference in partial prothrombin time between the two groups(P>0.05).After treatment,the levels of TNF-α,IL-6 and IL-8 in the observation group were(50.18±2.46)ng/L,(1.43±0.29)ng/L and(181.34±16.23)ng/L,which were lower than those in the control group(65.81±3.22)ng/L,(2.10±0.31)ng/L and(214.34±19.40)ng/L,and the differences were statistically significant(t=20.772,8.500,7.026,P<0.05).After treatment,the quality of life scores in the observation group were significantly higher than those of the control group,and the differences were statistically significant(t=2.960,7.173,P<0.05).Conclusion Argatroban can effectively improve the neurological function injury,control the coagulation index,reduce the inflammatory index,and improve the quality of life in patients with acute ischemic stroke.