肿瘤浸润B细胞与免疫治疗

Tumor infiltrating B cells and immunotherapies

B细胞是肿瘤微环境的重要成分,然而,B细胞对肿瘤进展及治疗响应的影响目前仍然存在争议,这反映了肿瘤浸润B细胞(Tumor infiltrating B cells, TIL-Bs)亚群的异质性。事实上,这些TIL-Bs随着所处的免疫微环境向不同的方向极化进而获得不同的表型及功能,同时也反向塑造着微环境的组成及类型,最终导致了截然不同的临床预后。本文总结了TIL-Bs的组成特征及形成机制。进一步结合临床试验及临床前研究,我们尝试解释TIL-Bs的异质性对肿瘤免疫治疗效果的影响。阐明肿瘤中B细胞亚群的组成、产生和相关免疫网络的性质对于全面了解肿瘤中的B细胞反应,设计更有效的癌症免疫疗法具有重要意义。

B cells are an critical component of the tumor microenvironment.However, the impact of B cells on tumor progression and treatment response is still controversial, reflecting the heterogeneity of tumor infiltrating B cells(TIL-Bs)subsets.In fact, these TIL-Bs are polarized in different directions with the immune microenvironment in which they are located to obtain different phenotypes and functions, and at the same time reversely shape the composition and type of the microenvironment, eventually leading to completely different clinical outcomes.This article summarizes the composition characteristics and formation mechanism of TIL-Bs.Further, combined with clinical trials and preclinical studies, we try to explain the influence of TIL-Bs heterogeneity on the effect of tumor immunotherapy.Elucidating the composition, generation, and nature of associated immune networks of B cell subsets in tumors are of great importance for a comprehensive understanding of B cell responses in tumors and for the design of more effective cancer immunotherapies.