血清及胸水细胞块中CEA、CA125检测对肺腺癌的诊断价值

Diagnostic value of CEA and CA125 in serum and pleural effusion cell blocks in lung adenocarcinoma

目的:比较不同方法检测不同类型标本中CEA、CA125对肺腺癌的诊断价值。方法:采用电化学发光和免疫组织化学两种不同的方法分别检测肺腺癌及良性疾病患者的外周血、胸水细胞块中CEA、CA125的表达,分析两种检测方法的诊断效能及一致性。结果:肺癌组患者血清和组织CA125、CEA水平均显著高于良性肺病组,诊断效能方面两种方法略有差别,两种方法检测CEA一致性程度中等,CA125一致性较差。结论:CEA和CA125在良恶性胸腔积液鉴别诊断方面有重要价值,血清检测具有较高的敏感性,免疫组化方法特异性更高,两种方法相互补充有助于明确诊断。

Objective:To investigate the diagnostic value of CEA and CA125 in different types of samples.Methods:Detect the expression of CEA and CA125 in serum and pleural effusion cell blocks in adenocarcinoma and benign disease patients using different method respectively,and analyze the diagnostic efficacy and consistency of the two methods.Results:The serum and tissue levels of CEA and CA125 in the lung adenocarcinoma group were significantly higher than those in the benign disease group.The two methods were different in terms of diagnostic efficacy.The consistency between the two methods for CEA is moderate,but that of CA125 is poor.Conclusion:CEA and CA125 have important value in the differential diagnosis of benign and malignant disease.Serum detection has higher sensitivity,but immunohistochemical method has higher specificity.The two methods complement each other to improve diagnostic accuracy.