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无偿献血大学生的乙肝筛查情况

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摘要 目前,我国输血前血液筛查模式为首先采用酶联免疫吸附试验(ELISA)检测乙型肝炎表面抗原(HBsAg),将大部分乙肝传播者屏蔽;HBsAg阴性的标本再采用核酸检测(NAT)检测乙肝病毒脱氧核糖核酸(HBV-DNA),达到缩短窗口期,尽量减少隐匿性乙型肝炎病毒感染(OBI)者献血传播乙肝的目的[1]。
作者 潘微 陈玉凤 李冰 任丽萍
机构地区 锦州市全民健康保障中心(锦州市中心血站) 大连市疾病预防控制中心 大连医科大学附属第一医院检验科 辽宁省疾病预防控制中心
出处 《中国冶金工业医学杂志》 2022年第6期736-738,共3页 Chinese Medical Journal of Metallurgical industry
关键词 乙肝病毒脱氧核糖核酸 HBSAG阴性 血液筛查 输血前 献血 窗口期
分类号 R446.6 [医药卫生—诊断学]
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  • 1Zou S, Dorsey KA, Notari EP, et al. Prevalence, incidence, and residual risk of human immunedeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testing. Transfusion, 2010, 50(7) :1495-1504.
  • 2Zou S, Strainer S, Notari EP, et al. Current incidence and residu- al risk of hepatitis B infection among blood donors in the United States. Transfusion, 2009, 49 ( 8 ) : 1609-1620.
  • 3Nubling CM, Heiden M, Chudy M, et al. Experience of mandato- ry nucleic acid test (NAT) screening across all blood organizations in Germany: NAT yield versus breakthrough transmissions. Trans- fusion, 2009, 49(9) :1850-1858.
  • 4Weusten JJ, Vermeulen M, van Drimmelen HA, et al. Refinement of a viral transmission risk model for blood donations in seroconer- sion window phase screened by nucleic acid testing in different pool sizes and repeat test algorithms. Transfusion, 2011, 51 (1) :203- 215.
  • 5Lin KT, Chang CL, Tsai MH, et al. Detection and identification of occult HBV in blood donors in Taiwan using commercial, multi- plex, multi-dyenucleic acid amplification technology screening test. Vox Sang, 2014, 106(2) :103-110.
  • 6Salles NA, Levi JE, Barreto CC, et al. Human immunodeficiency virus transfusion transmission despite nucleic acid testing. Transfu- sion, 2013, 53( 10 Pt 2) :2593-2595.
  • 7V Shyamala. Nucleic acid technology (NAT) testing for blood screening impact of individual donation and mini pool-NAT testing on analytical sensitivity, screening sensitivity and clinical sensitivi- ty. ISBT Science Series, 2014, 9(2) :315-324.
  • 8FDA. Guidance for industry: use of nucleic acid tests on pooled and individual samples from donors of whole blood and blood com- ponents, including source plasma, to reduce the risk of transmis- sion of hepatitis B virus. 2014-10-1212015-03-16] http://www. fda. gov/downloads/BiologicsBloodVaccines/GuidanceCompliance- Regulatorylnformation/Guidances/Blood/UCM327895. pdf.
  • 9Weusten J, Vermeulen M, van Drimmelen H, Lelie N. Refine- ment Of a viral transmission risk model for blood donations in sero- conversion window phase screened by nucleic acid testing in differ- ent pool sizes and repeat'test algorithms. Transfusion, 2011, 51 (1) :203-215.
  • 10Margaritis A, Seed C, Ismay S, Kiely P, Keller A. Implications of non reproducible HIV-1/HCV multiplex reactive donations screened using individual donation NAT. Transfusion, 2008, 48 (9) :45-48,.

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中国冶金工业医学杂志
2022年 第6期

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