外泌型汗腺参与创面愈合的研究进展

Advances in research on the involvement of eccrine sweat glands in wound healing

表皮和毛囊的干细胞都参与皮肤创面的愈合,但人们对外泌型汗腺在创面愈合过程中的作用知之甚少。本文简述了外泌型汗腺的结构特点与发育过程、外泌型汗腺细胞参与创面再上皮化、血管化的作用和机制以及汗腺类器官体外构建的实验研究,这些实验研究分析表明了外泌型汗腺不仅具有分泌汗液调节体温的作用,而且在参与创面再上皮化、血管化中也具有重要作用,由此指出体外汗腺类器官的培育不仅能实现皮肤功能重建,也能参与创面愈合。

Stem cells from both the epidermis and hair follicles are involved in the healing of skin wounds,but little is known about the role of eccrine sweat glands in the process of wound healing.This paper briefly describes the structural characteristics and developmental process of eccrine sweat glands,the role and mechanism of eccrine sweat gland cells involved in wound re-epithelialisation and vascularisation,and experimental studies on the in vitro construction of sweat gland-like organs.The analysis of these experimental studies has shown that eccrine sweat glands not only have a role in the regulation of body temperature through the secretion of sweat,but also play an important role in the re-epithelialisation and vascularisation of wounds,suggesting that the cultivation of sweat gland-like organs in vitro can not only lead to the reconstruction of skin function,but also to the healing of wounds.