体检人群甲状腺功能指标与14种食物不耐受检测结果的关系

Relationship between the blood test results of thyroid function and intolerance to 14 kinds of foods in physical examination population

目的探讨体检人群血液甲状腺功能指标与14种食物不耐受检测结果的关系。方法选取2016年8月至2019年9月来解放军总医院体检并进行食物不耐受和甲状腺功能七项检测者, 共45 764名作为研究对象;结合年龄、性别、体质指数、吸烟和饮酒情况以及实验室化验指标, 采用卡方检验、单因素或多因素logistics回归分析甲状腺功能指标与14种食物不耐受的关系。结果在研究对象中, 29 361名(64.16%)存在至少一种食物不耐受阳性, 其中1级15 011名(32.80%), 2级9 037名(19.75%), 3级5 313名(11.61%)。在14种食物中, 鸡蛋不耐受的阳性率最高(34.06%), 牛肉最低(1.24%)。共有11 337名(24.77%)至少有一项甲状腺功能存在异常, 异常率最高的是血清促甲状腺激素, 其次是抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体。综合食物不耐受阳性人群的甲状腺功能异常比例(26.32%)明显高于综合食物不耐受阴性人群(22.00%), 差异有统计学意义(χ2=105.78, P<0.001)。经校正其他显著相关的因素后, 综合食物不耐受阳性仍是甲状腺功能异常的显著影响因素(OR=1.14, Z=5.68, 95%CI:1.09~1.20, P<0.001)。校正了年龄、性别、吸烟和饮酒因素后, 常见的4种食物包括鸡蛋(Z=4.31)、大豆(Z=4.06)、螃蟹(Z=3.48)、猪肉(Z=2.84)的不耐受与甲状腺功能异常的具有相关性(均P<0.001)。结论食物不耐受是甲状腺功能异常的一个危险因素。其中, 国人经常食用的鸡蛋、大豆、螃蟹、猪肉可能是最应该重点关注的食物品种。

Objective To investigate the relationship between the blood test results of seven items of thyroid function and intolerance to 14 kinds of foods in physical examination population.Methods Total of 45764 participants who received physical examination and accepted 14-kind food intolerance and 7-item thyroid function detection from August 2016 to September 2019 in Chinese People′s Liberation Army General Hospital were included in this study.The data were analyzed based on age,gender,body mass index,smoking and drinking status,and laboratory test indexes.Chi square test and univariate or multivariate logistic regression were applied to analyze the correlation between food intolerance and thyroid function in the physical examination population.Results In the subjects,there were 29361 cases(64.16%)with at least intolerance to one kind of food,and 15011(32.80%)were in Grade 1,9037(19.75%)in grade 2 and 5313(11.61%)in grade 3.The positive rate of egg intolerance was the highest(34.06%),and that of beef intolerance was the lowest(1.24%).Of the participants,11337(24.77%)had at least one item thyroid dysfunction,among them,the highest abnormal rate was found in thyroid stimulating hormone(TSH),followed by anti-thyroglobulin antibodies and anti-thyroid peroxidase antibodies.The proportion(26.32%)of abnormal thyroid function in the participants with at least intolerance to one kind of food was significantly higher than that(22.00%)in the participants without intolerance to the 14 kinds of foods(χ2=105.78,P<0.001).After adjusting for other significantly related factors,the positive results of intolerance to 14 kinds of foods was still the significant influencing factor of thyroid function abnormalities(OR=1.14,Z=5.68,95%CI:1.09-1.20,P<0.001).Further analysis showed that,after adjusted for age,gender,smoking and drinking status,intolerance to four kinds of foods(egg,soybean,crab and pork)were the significant influencing factors of abnormal thyroid function.Conclusions Food intolerance is an independent risk factor of thyroid dysfunction.Among them,egg,soybean,crab and pork may be the most important food varieties should be paid more attention to.