嗜神经病毒穿越血脑屏障入侵中枢神经系统的相关致病机制研究进展

Progress in pathogenic mechanisms of neurotropic viruses crossing blood-brain barrier and invading central nervous system

血脑屏障是位于血液与脑组织之间的天然屏障,可严格控制血液中的感染性病原体入侵大脑,维持大脑内环境稳定。然而,嗜神经病毒却能破坏或逃避血脑屏障入侵脑部,引发脑炎或脑膜炎等严重的中枢神经系统并发症,有些甚至威胁生命。本文主要对一些较常见的嗜神经病毒穿越血脑屏障入侵大脑的不同致病机制研究进展进行综述。

Blood-brain barrier is a natural barrier between blood and brain tissue that can protect the brain from invasion by infectious pathogens in blood and maintain the homeostasis of the brain environment.However,neurotropic viruses can escape or disrupt blood-brain barrier and then invade the brain,causing serious complications in the central nervous system such as encephalitis and meningitis,which seriously threaten human life.This paper mainly summarized the research progress in the pathogenic mechanisms of common neurotropic viruses crossing blood-brain barrier and invading the central nervous system.