基于ORTCC的成人结直肠癌患者围术期口服营养补充最佳证据总结

Best evidence summary of perioperative oral nutritional supplements in adult colorectal cancer patients based on ORTCC model

目的 检索及筛选成人结直肠癌患者围术期口服营养补充的最佳证据,结合ORTCC模型进行总结,为优化临床口服营养补充实施流程提供参考。方法 依据“6S”模型检索国内外数据库及专业网站中关于成人结直肠癌患者围术期口服营养补充相关的证据,包括临床决策信息册、指南、专家共识、证据总结、系统评价,进行文献质量评价,参考ORTCC模型提取并汇总相关证据。结果 共纳入18篇文献,其中包括7篇指南、6篇专家共识、2篇证据总结、3篇系统评价,总结5个维度26条证据。结论 基于ORTCC的成人结直肠癌患者围术期口服营养补充最佳证据总结为临床实践提供循证依据,需结合临床实际加以应用,提高营养治疗效果,使患者受益。

Objective To retrieve and screen the best evidence of oral nutritional supplements in perioperative adult colorectal cancer patients, summarize the best evidence under the ORTCC model, so as to provide a reference for optimizing the clinical implementation process of oral nutritional supplements.Methods Based on the ‘6 S’ pyramid model, the literatures and evidence relevant to pe-rioperative oral nutritional supplements of adult colorectal cancer patients were retrieved in domestic and overseas databases and professional websites, including clinical decision information book, guidelines, expert consensus, best evidence summaries and systematic reviews.Then the quality of evidence and literatures were evaluated, and included literatures were extracted and summarized referring to the ORTCC model.Results A total of 18 literatures were included, consisting of 7 guidelines, 6 expert consensus, 2 best evidence summaries and 3 systematic reviews.Finally, 26 pieces of best evidence in 5 dimensions were summarized.Conclusion The best evidence summary of oral nutritional supplements in perioperative adult colorectal cancer patients based on the ORTCC model, provides evidence for clinical practice.The evidence needs to be adjusted for different conditions to improve the efficacy of nutritional therapy and benefit patients.