摘要
目的荟萃分析探究MxA蛋白对呼吸道病毒感染的诊断价值。方法在EMbase、PubMed和the Cochrane Library以及中国生物医学文献服务系统、知网、万方数据库检索建库至2022年1月相关文献。研究者按照标准,筛选符合文献,用QUADAS-2工具进行质量评价,用Revman 5.3绘制偏倚风险图,使用Stata 15.0软件进行数据分析。结果共纳入14篇文献。文献质量偏倚风险较低,适用性较好。单独MxA分析结果:异质性检验灵敏度Q=15.71,P=0.02,I^(2)=61.80%,特异度Q=11.07,P=0.09,I^(2)=45.81%。合并灵敏度(Sen)=0.91(95%CI:0.86,0.94)、合并特异度(Spe)=0.89(95%CI:0.83,0.93)、合并阳性似然比(PLR)=8.20(95%CI:5.20,12.80)、合并阴性似然比(NLR)=0.10(95%CI:0.07,0.16)、合并诊断比值比(DOR)=79.00(95%CI:45.00,141.00),综合受试者工作特征(SROC)曲线曲线下面积AUC=0.96(95%CI:0.93,0.97)。FebriDX(MxA+CRP)分析结果:灵敏度Q=75.87,P<0.05且I^(2)=92.09%;特异度检验Q=17.79,P<0.05且I^(2)=66.27%,灵敏度、特异度的异质性有统计学意义。Sen=0.91(95%CI:0.80,0.97)、Spe=0.86(95%CI:0.80,0.91)、PLR=6.60(95%CI:4.40,10.00)、NLR=0.10(95%CI:0.04,0.25)、DOR=65.00(95%CI:19.00,222.00),SROC曲线下面积AUC=0.92(95%CI:0.89,0.94)。结论MxA蛋白对呼吸道病毒感染有一定的诊断价值。
Objective Meta-analysis was used to investigate the diagnostic value of MxA protein for respiratory virus infection.Methods EMbase,PubMed,the Cochrane Library,China Biology Medicine(CBM),China National Knowledge Infrastructure(CNKI),and Wanfang databases were searched from the inception of these databases up to January 2022 to retrieve relevant studies on MxA protein.According to the inclusion and exclusion criteria,two researchers selected the eligible references for quality evaluation based on QUADAS-2 standard.Revman 5.3 software was used to plot the risk of bias.Stata 15.0 software was used to perform data analysis.Results A total of 14 studies were included,for which the overall risk of bias was low.For diagnosis of respiratory virus infection,MxA alone showed sensitivity Q=15.71,P=0.02,I^(2)=61.80%,specificity Q=11.07,P=0.09,I^(2)=45.81%.Meta-analysis indicated that the pooled sensitivity was 0.91(95%CI:0.86,0.94).Pooled specificity was 0.89(95%CI:0.83,0.93).Pooled positive likelihood ratio(PLR)was 8.20(95%CI:5.20,12.80).Pooled negative likelihood ratio(NLR)was 0.10(95%CI:0.07,0.16).Pooled diagnostic odds ratio(DOR)was 79.00(95%CI:45.00,141.00).The area under the summary receiver operating characteristic(SROC)curve was 0.96(95%CI:0.93,0.97).The rapid diagnostic test FebriDx showed sensitivityQ=75.87,P<0.05,I^(2)=92.09%,and specificity Q=17.79,P<0.05,I^(2)=66.27%.Meta-analysis demonstrated that the pooled sensitivity was 0.91(95%CI:0.80,0.97).Pooled specificity was 0.86(95%CI:0.80,0.91).Pooled PLR was 6.60(95%CI:4.40,10.00).Pooled NLR was 0.10(95%CI:0.04,0.25).Pooled DOR was 65.00(95%CI:19.00,222.00).The area under the SROC curve was 0.92(95%CI:0.89,0.94).Deeks’funnel plot did not show significant difference in publication bias among the studies.Conclusions MxA protein has certain diagnostic value for respiratory virus infection.
作者
邹悦
何世伟
赵丽
葛胜祥
叶辉铭
ZOU Yue;HE Shiwei;ZHAO Li;GE Shengxiang;YE Huiming(School of Public Health,Xiamen University,Xiamen Fujian 361000,China)
出处
《中国感染与化疗杂志》
CAS
CSCD
北大核心
2022年第6期663-669,共7页
Chinese Journal of Infection and Chemotherapy
基金
福建省卫生健康委员会医学科研计划项目(2021ZD01006)。