肿瘤坏死因子耐受的特点及其分子机制

Characteristics and molecular mechanism of tumor necrosis factor tolerance

目的总结评估肿瘤坏死因子(tumor necrosis factor,TNF)耐受的意义,了解不同形式耐受的一般特征和已知的分子机制,包括转录因子、信号系统和受体的作用。方法收集阅读近几年国内外的相关文献,对TNF耐受相关内容进行总结。结果经TNF预处理后可产生TNF耐受,TNF耐受分为了绝对耐受和诱导耐受;TNF耐受与多种相互联系且相互依赖的细胞内信号转导相关;TNF与脂多糖存在交叉耐受。结论TNF耐受可能代表了一种保护性机制,参与了炎症的终止和防止炎症过度或持续;TNF耐受也可能触发免疫瘫痪,从而导致严重的炎症性疾病,如脓毒症。对TNF耐受的认识可促进炎症相关疾病的诊断或治疗方法的实施,做到更精准的评估和治疗。

Objective To summarize and evaluate the significance of tumor necrosis factor(TNF)tolerance,and to understand the general characteristics and known molecular mechanisms of different forms of tolerance,including the roles of transcription factors,signaling systems and receptors.Method The relevant literatures at home and abroad in recent years were collected and readed,and the content related to TNF tolerance was summarized.Results TNF tolerance could be produced after TNF pretreatment,and be divided into absolute tolerance and induced tolerance.TNF tolerance was related to a variety of interrelated and interdependent intracellular signal transduction.There was cross tolerance between TNF and lipopolysaccharide.Conclusions TNF tolerance may represent a protective mechanism,participating in the termination of inflammation and preventing excessive or persistent inflammation.TNF tolerance may also trigger immune paralysis,leading to severe inflammatory diseases,such as sepsis.The understanding of TNF tolerance can promote the diagnosis of inflammation related diseases or the implementation of treatment methods,so as to achieve more accurate evaluation and treatment.