摘要
The development of synthetic polymers that mimic the double-stranded helical structure of DNA is a fascinating topic in polymer science.In this study,we designed and synthesized two chiral norbornene monomers containing adenine and thymine,which were mixed to form a hydrogen-bonding complementary complex,by which a ring-opening metathesis polymerization(ROMP)was performed.High-resolution transmission electron microscopy(HRTEM)undoubtedly showed the self-assembly of the optically active complementary nucleobasefunctionalized polynorbornenes into a double helix.Computer simulations and a two-dimensional nuclear Overhauser effect spectroscopy(2DNOESY)experiment showed that the doublestranded helical polynorbornene was derived from a copolymer of alternating adenine and thymine units.
基金
The authors thank the National Natural Science Foundation of China(grant no.21971037)
the Jiangsu Provincial Natural Science Foundation of China(grant no.BK20170024)for the support of this research project.
