高甘油三酯血症性急性胰腺炎研究进展

Research Progress in Hypertriglyceridemia-Induced Acute Pancreatitis

高甘油三酯血症性急性胰腺炎(HTGAP)是指由严重的高甘油三酯血症(HTG)诱发的急性胰腺炎(AP)。近年来HTGAP发病率逐年升高,且较其他类型的AP具有年轻化、病情重、并发症发生率高、易复发等特点。HTGAP的治疗除了AP的常规治疗手段外,最关键的是在发病早期进行紧急降脂治疗以阻止病情发展。文章总结了近年来国内外最新研究证据,就HTGAP的病因、发病机制、治疗进展作一综述,重点阐述了包括口服药物、胰岛素注射、血液净化、基因治疗等各种降脂治疗的研究进展。

Hypertriglyceridemia-induced acute pancreatitis(HTGAP)refers to acute pancreatitis caused by severe hypertriglyceridemia.In recent years,the incidence of HTGAP has been increasing year by year.Compared with other types of acute pancreatitis,HTGAP is characterized by younger age,severe disease,high incidence of complications and easy recurrence.In addition to the conventional treatment of acute pancreatitis,the most critical treatment of HTGAP is the emergency lipid-lowering treatment at the early stage to prevent the development of the disease.This paper summarizes the latest research evidence at home and abroad in recent years,and reviews the etiology,pathogenesis and treatment of HTGAP,focusing on the research progress in various lipid-lowering treatments,including oral drugs,insulin injection,blood purification and gene therapy.