中医导引干预帕金森病失眠患者临床研究

Clinical Study on Intervention of Traditional Chinese Medicine Conduction Exercise for Insomnia in Patients with Parkinson’s Disease

目的:探讨中医导引对帕金森病失眠患者睡眠质量、生活质量以及相关血清学指标的影响。方法:将68例帕金森病失眠患者随机分为对照组和观察组,两组患者均接受帕金森病常规治疗,观察组在此基础上实施中医导引治疗,干预8周后对两组患者匹兹堡睡眠质量指数(PSQI)评分、多导睡眠图(PSG)睡眠参数、血清5-羟色胺(5-HT)及褪黑素(MT)含量、帕金森患者生活质量问卷(PDQ-39)评分进行评估比较。结果:干预前,两组患者PSQI评分、PSG睡眠参数(睡眠潜伏期、觉醒次数、觉醒时间)、PDQ-39评分以及血清5-HT、MT水平比较,差异无统计学意义(P>0.05)。干预后,两组患者PSQI评分、PDQ-39评分均较干预前降低,且观察组低于对照组,差异有统计学意义(P<0.05);PSG睡眠参数(睡眠潜伏期、觉醒次数、觉醒时间)均较干预前改善,且观察组优于对照组,差异有统计学意义(P<0.05);血清5-HT、MT水平均较干预前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:中医导引能够调节睡眠-觉醒周期,从而改善帕金森病失眠患者睡眠质量,提高患者生活质量。

Objective:To investigate the effects of traditional Chinese medicine(TCM)conduction exercise on sleep quality,quality of life and related serological indexes in Parkinson’s disease insomnia patients.Methods:A total of 68 patients with Parkinson’s disease insomnia were randomly divided into control group and observation group,both groups received conventional treatment for Parkinson’s disease,and the observation group was treated with TCM conduction exercise on this basis.After 8 weeks of intervention,Pittsburgh Sleep Quality Index(PSQI)scores,polysomnography(PSG)sleep parameters,serum 5-hydroxytryptamine(5-HT)and melatonin(MT)content,and Parkinson’s Disease Questionnaire(PDQ-39)score were evaluated and compared between the two groups.Results:Before the intervention,the differences of PSQI scores,PSG sleep parameters(sleep latency,number of awakenings,awakening time),PDQ-39 score and serum 5-HT and MT levels between the two groups were not statistically significant(P>0.05).After the intervention,the PSQI scores and PDQ-39 score of both groups were lower than those before the intervention,the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The PSG sleep parameters(sleep latency,number of awakenings,awakening time)were all improved compared with those before the intervention,and those of the observation group were better than those of the control group,and the differences were statistically significant(P<0.05).The levels of serum 5-HT and MT were higher than those before the intervention,and those of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion:TCM conduction exercise can regulate the sleep-wake cycle,thus improving the sleep quality of patients with Parkinson’s disease insomnia and improving their quality of life.