子宫内膜容受性转录组学研究进展

Research progress of transcriptomic study in endometrial receptivity

胚胎植入依赖于良好的胚胎质量、子宫内膜容受性,及胚胎-子宫内膜间同步和谐地交流对话。相较于发展较成熟的胚胎培养技术,目前子宫内膜容受性仍缺乏有效的诊断与治疗方法,传统检测方法如胞饮突检测、组织学检测、超声等,其准确性和可重复性饱受质疑。随着组学技术的发展,利用基因表达的整体特征描述、诊疗疾病已成为可能,其在子宫内膜容受性领域也具有较大的研究和临床运用价值。本文就近年来子宫内膜容受性领域转录组学临床研究作一综述,概括子宫内膜容受性相关编码基因、非编码基因研究的基本情况及临床运用情况,为后续研究子宫内膜容受性、指导临床诊疗提供参考。

Embryo implantation is a complex process that relies on elaborate cooperation between the well-qualified embryo and endometrial receptivity,and synchronous and harmonious communication between embryo and endometrium.Compared with the well-developed embryo culturing technology,there is a lack of effective diagnosis and treatment of endometrial receptivity.Traditional diagnostic tools,including pinopode analyzing,histologic dating,ultrasound,etc.are being questioned for accuracy and reproducibility.However,with the great development of omics,describing diseases in a gene expression whole pattern becomes feasible,which shows potential clinical value.The review focuses on the research progress of transcriptomic study in endometrial receptivity and concludes receptivity-related coding and non-coding RNAs,laying foundations for further research and clinical applications.