定向微孔镁掺杂羟基磷灰石生物陶瓷降解及其生物学性能研究

Study on the degradation and biological properties of directional microporous magnesium doped hydroxyapatite bioceramics

多孔羟基磷灰石(Ca_(10)(PO_(4))_(6)(OH)_(2),HA)陶瓷有利于骨细胞的粘附、迁移和增殖分化,能促进骨骼生长和诱导早期新骨的形成,因此在骨缺损的修复领域具有较大的应用潜力.然而,生物学性能和力学性能的难以平衡限制了复合材料在骨组织工程中的应用.在保持多孔陶瓷力学性能的基础上,以提升生物活性为目标,通过HA陶瓷内部微孔结构的引入和材料成分的改变(Mg离子的掺杂)获得生物学性能优异的微孔Mg-HA人工骨材料.结果表明:微孔Mg-HA呈现出最快的降解速率,分别比致密Mg-HA和HA质量损失率提高了43.3%和364.41%.优异的成骨性能和降解性归功于微孔Mg-HA定向微通道的促进作用,制备的定向微孔Mg-HA在骨修复(特别是在承重骨缺损修复)领域显示出巨大的潜力.

Porous hydroxyapatite(Ca_(10)(PO_(4))_(6)(OH)_(2),HA)ceramics can promote the adhesion,migration,proliferation and differentiation of bone cells,promote bone growth and induce the formation of early new bone.Therefore,it has great application potential in the field of bone defect repair.However,the difficult balance between biological and mechanical properties limits the application of composite materials in bone tissue engineering.In this paper,microporous Mg-HA artificial bone material with excellent biological properties was obtained by introducing microporous structure and changing material composition(magnesium ion doping)in HA ceramics.The results showed that microporous Mg-HA showed the fastest degradation rate,and the mass loss rate of microporous Mg-HA was 43.3%and 364.41%higher than that of compact Mg-HA and HA,respectively.The excellent osteogenic properties and degradability are attributed to the promotion of microporous Mg-HA directional microchannels.The prepared microporous Mg-HA directional microchannels show great potential in bone repair,especially in the field of weight-bearing bone defect repair.