摘要
目的:观察雌二醇片/雌二醇地屈孕酮片复合包装治疗围绝经期综合征患者的效果。方法:回顾性分析2019年12月至2021年4月该院收治的106例围绝经期综合征患者的临床资料,根据治疗方式不同将其分为对照组和观察组各53例。对照组采用戊酸雌二醇片/雌二醇环丙孕酮片复合包装治疗,观察组采用雌二醇片/雌二醇地屈孕酮片复合包装治疗,比较两组临床疗效、治疗前后性激素指标[促黄体生成激素(LH)、雌二醇(E_(2))、卵泡刺激素(FSH)]水平、生命质量[围绝经期综合征生活质量评定量表(MENQOL)]评分和治疗期间不良反应发生率。结果:观察组治疗总有效率为98.11%(52/53),高于对照组的83.02%(44/53),差异有统计学意义(P<0.05);治疗后,两组LH、FSH水平均低于治疗前,且观察组低于对照组,两组E_(2)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组血管舒缩症状、心理症状、生理症状和性生活症状等MENQOL评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:雌二醇片/雌二醇地屈孕酮片复合包装治疗围绝经期综合征患者可提高治疗总有效率,改善性激素指标水平,降低MENQOL评分,效果优于戊酸雌二醇片/雌二醇环丙孕酮片复合包装治疗。
Objective:To observe effects of complex packing Estradiol tablets/Estradiol and Dydrogesterone tablets in treatment of patients with perimenopausal syndrome.Methods:The clinical data of 106 patients with perimenopausal syndrome admitted to the hospital from December 2019 to April 2021 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,53 cases in each.The control group was treated with complex packing Estradiol valerate tablets,Estradiol valerate and Cyproterone acetate tablets,while the observation group was treated with complex packing Estradiol tablets/Estradiol and Dydrogesterone tablets.The clinical efficacy,the sex hormone index levels[luteinizing hormone(LH),estradiol(E_(2)),follicle stimulating hormone(FSH)]before and after the treatment,the quality of life[menopause-specific quality of life(MENQOL)]score,and the incidence of adverse reactions during treatment were compared between the two groups.Results:The total effective rate of treatment in the observation group was 98.11%(52/53),which was higher than 83.02%(44/53)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LH and FSH in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of E_(2) in the two groups were higher than those before the treatment,and that of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).After the treatment,the MENQOL scores of vasomotor symptoms,psychological symptoms,physical symptoms and sexual life symptoms in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Complex packing Estradiol tablets/Estradiol and Dydrogesterone tablets can improve the total effective rate of treatment,improve the levels of sex hormone indexes and reduce the MENQOL scores in the patients with perimenopausal syndrome.Moreover,it is superior to complex packing Estradiol valerate tablets,Estradiol valerate and Cyproterone acetate tablets.
作者
王鹏
武文慧
吉柳
WANG Peng;WU Wenhui;JI Liu(Pharmacy Department of Dalian Municipal Women and Children's Medical Center(Group),Dalian 116035 Liaoning,China)
出处
《中国民康医学》
2022年第24期18-21,共4页
Medical Journal of Chinese People’s Health
关键词
雌二醇片/雌二醇地屈孕酮片复合包装
围绝经期综合征
促黄体生成激素
卵泡刺激素
雌二醇
生命质量
Complex packing Estradiol tablets/Estradiol and Dydrogesterone tablets
Perimenopausal syndrome
Luteinizing hormone
Follicle stimulating hormone
Estradiol
Quality of life