坤泰胶囊联合激素替代疗法治疗卵巢早衰患者的效果

Effects of Kuntai capsules combined with hormone replacement therapy on patients with premature ovarian failure

目的:研究坤泰胶囊联合激素替代疗法治疗卵巢早衰患者的效果。方法:回顾性分析2019年6月至2021年6月该院收治的103例卵巢早衰患者的临床资料,根据治疗方法不同分为对照组51例和观察组52例。对照组采用激素替代疗法(戊酸雌二醇片+黄体酮软胶囊)治疗,观察组在对照组基础上加用坤泰胶囊。治疗3个月后,比较两组临床疗效、治疗前后性激素指标[卵泡刺激素(FSH)、雌二醇(E_(2))、黄体生成素(LH)]水平、窦卵泡计数(AFC)、子宫内膜厚度、改良Kupperman量表评分、血流动力学指标[卵巢动脉收缩期峰值流速(PSV)、阻力指数(RI)、搏动指数(PI)]水平,以及不良反应发生率。结果:观察组治疗总有效率为92.31%(48/52),高于对照组72.55%(37/51),差异有统计学意义(P<0.05);治疗3个月后,观察组Kupperman评分低于对照组,差异有统计学意义(P<0.05);治疗3个月后,观察组FSH、LH水平均低于对照组,E_(2)水平高于对照组,差异有统计学意义(P<0.05);治疗3个月后,观察组AFC数量多于对照组,子宫内膜厚度厚于对照组,差异有统计学意义(P<0.05);治疗3个月后,观察组RI、PI均低于对照组,PSV高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:坤泰胶囊联合激素替代疗法治疗卵巢早衰患者能提高疗效,改善患者性激素水平和卵巢血流动力学指标水平,缓解其临床症状,且安全性较高,效果优于单用激素替代疗法。

Objective:To study effects of Kuntai capsules combined with hormone replacement therapy on patients with premature ovarian failure.Methods:The clinical data of 103 patients with premature ovarian failure admitted to this hospital from June 2019 to June 2021 were retrospectively analyzed.According to different treatment methods,they were divided into control group(51 cases)and observation group(52 cases).The control group was treated with hormone replacement therapy(Estradiol valerate tablets+Progesterone soft capsules),while the observation group was treated with Kuntai capsules on the basis of that of the control group.After 3 months of treatment,the clinical efficacy,the sex hormone levels[follicle stimulating hormone(FSH),estradiol(E_(2)),luteinizing hormone(LH)],the antral follicle count(AFC),the endometrial thickness,the modified Kupperman scale score,the hemodynamic index levels[ovarian artery peak systolic velocity(PSV),resistance index(RI),pulsatility index(PI)],and the adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.31%(48/52),which was higher than the control group of 72.55%(37/51),and the difference was statistically significant(P<0.05).After 3 months of treatment,the Kupperman score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the levels of FSH and LH in the observation group were lower than those in the control group,and the level of E_(2) was higher than that in the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the number of AFC in the observation group was more than that in the control group,and the endometrial thickness was thicker than that in the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the RI and PI levels in the observation group were lower than those in the control group,and the PSV level was higher than that in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Kuntai capsules combined with hormone replacement therapy in the treatment of the patients with premature ovarian failure can improve the efficacy,improve the patients’sex hormone levels and the ovarian hemodynamic index levels,relieve their clinical symptoms,and high safety.Moreover,it is superior to single hormone replacement therapy.