血清5'-NT、GGT、MAO水平检测在原发性肝癌诊断中的效能

Efficacy of serum 5’-NT,GGT and MAO levels in diagnosis of primary liver cancer

目的:分析血清5'-核苷酸酶(5'-NT)、γ-谷氨酰转移酶(GGT)、单胺氧化酶(MAO)水平检测在原发性肝癌(HCC)诊断中的效能。方法:回顾性分析2020年2月至2021年5月该院收治的45例HCC患者的临床资料作为研究组,同时选择同期该院收治的45例良性肝病患者作为对照1组,另选择同期于该院体检的45例健康体检者作为对照2组。比较三组血清5'-NT、GGT、MAO水平,并绘制受试者工作特征曲线(ROC),分析血清5'-NT、GGT、MAO水平单项与联合检测诊断HCC的效能。结果:研究组血清5'-NT、GGT、MAO水平均高于对照1组和对照2组,且对照1组高于对照2组,差异有统计学意义(P<0.05);绘制ROC曲线,得到血清5'-NT、GGT、MAO单项与联合检测诊断HCC的AUC分别为0.809、0.895、0.762和0.930,且联合检测诊断的灵敏度高于单项检测。结论:血清5'-NT、GGT、MAO水平联合检测在HCC诊断中的灵敏度高于单项检测。

Objective:To analyze efficacy of serum 5'-nucleotidase(5'-NT),γ-glutamyltransferase(GGT)and monoamine oxidase(MAO)levels in diagnosis of primary liver cancer(HCC).Methods:The clinical data of 45 patients with HCC admitted to this hospital from February 2020 to May 2021 were retrospectively analyzed and they were set as study group.At the same time,45 patients with benign liver disease admitted to this hospital during the same period were selected as control group 1,and 45 healthy subjects who underwent physical examination were selected as control group 2.The levels of serum 5'-NT,GGT and MAO were compared among the three groups.The receiver operating characteristic curve(ROC)was plotted to analyze the efficacies of single and combined detection of serum 5'-NT,GGT and MAO levels in the diagnosis of HCC.Results:The levels of serum 5'-NT,GGT and MAO in the study group were higher than those in the control group 1 and the control group 2,those of the control group 1 were higher than those of the control group 2,and the differences were statistically significant(P<0.05).The ROC curve showed that the AUCs of serum 5'-NT,GGT and MAO in the diagnosis of HCC was 0.809,0.895,0.762 and 0.930,separately.Moreover,the sensitivity of combined detection was higher than that of single detection.Conclusions:The sensitivity of combined detection of serum 5’-NT,GGT and MAO in the diagnosis of HCC is higher than that of single detection.