卵巢颗粒细胞瘤诊治进展

Advances in Diagnosis and Treatment of Ovarian Granulosa Cell Tumor

卵巢颗粒细胞瘤(ovarian granulosa cell tumor,OGCT)起源于性索间质,相对罕见,约占卵巢肿瘤的2%~5%。按照组织病理学特点分为成人型颗粒细胞瘤(adult granulosa cell tumor,AGCT)和幼年型颗粒细胞瘤(juvenile granulosa cell tumor,JGCT)。因具有激素分泌功能临床上常表现为雌激素刺激症状。翼状螺旋/叉头转录因子2(forkhead transcription factor2,FOXL2)基因c.402C→G突变是AGCT的重要致病因素和分子诊断标记。手术是OGCT的首选治疗方法。临床分期是影响患者预后最重要的因素。抑制素β、抗苗勒管激素可作为诊断OGCT的血清学标志物。OGCT总体预后较好,因具有远期复发的特点,应坚持长期随访。

Ovarian granulosa cell tumor(OGCT)is a rare neoplasia of sex-cord stromal origin and accounts for 2%-5%of ovarian tumors.It can be divided into adult granulosa cell tumor(AGCT)and juvenile granulosa cell tumor(JGCT)according to the histopathological characteristics.Due to its secretion function,it often presents estrogen stimulation symptom.Mutation of FOXL2 gene c.402C→G is the most important pathogenic factor in AGCT and a molecular diagnostic marker.Surgery is the first choice for OGCT.The most important factor affecting the prognosis of patients is clinical stage.Inhibinβand AMH can be used as serological markers in diagnosis and detection of OGCT.OGCT generally has a favorable prognosis.Due to the characteristics of long-term recurrence,long-term follow-up should be insisted.