硫氧还蛋白相互作用蛋白在多囊卵巢综合征中作用的研究进展

Research Progress on the Role of Thioredoxin-Interacting Protein in Polycystic Ovary Syndrome

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种常见于育龄妇女的内分泌代谢性疾病,以月经不规则、高雄激素血症和卵巢多囊样改变为特征,常表现为肥胖、不孕和胰岛素抵抗。硫氧还蛋白相互作用蛋白(thioredoxin-interacting protein,TXNIP)是一种多功能调节剂,不仅参与胰岛素分泌和葡萄糖代谢的调节,还与氧化应激、炎症因子和情绪障碍密切相关。PCOS患者体内的TXNIP水平较健康人群明显增加,表明TXNIP可能参与PCOS及其并发症的发生、发展。近年体内外研究尝试应用中药提取物和西医药物抑制TXNIP的表达,TXNIP特异性抑制剂的发现使TXNIP有望成为抑制PCOS进程的有效靶点。综述TXNIP在PCOS中的作用进展,以期为PCOS发病机制的深入研究及临床诊疗提供新的思路和方向。

Polycystic ovary syndrome(PCOS)is an endocrine and metabolic disease commonly in women of reproductive age,characterized by irregular menstruation,hyperandrogenemia and polycystic ovary changes,often manifested as obesity,infertility and insulin resistance.Thioredoxin-interacting protein(TXNIP)is a multifunctional regulator that is not only involved in the regulation of insulin secretion and glucose metabolism,but also closely related to oxidative stress,inflammatory factors and mood disorders.Studies have shown that TXNIP levels are significantly increased in PCOS patients,suggesting that TXNIP may be involved in the development of PCOS and its complications.In recent years,some in vivo and ex vivo studies have attempted to use herbal extracts and western drugs to inhibit TXNIP expression,and the discovery of TXNIP-specific inhibitors makes it a promising and effective target to inhibit the process of PCOS.This article reviews the role of TXNIP in PCOS,in order to provide new ideas and directions for the in-depth study of PCOS pathogenesis and its clinical diagnosis and treatment.