HbA1c、C-P水平与2型糖尿病周围神经病变的关联性分析

Correlation analysis of HbA1c and C-P levels with type 2 diabetic peripheral neuropathy

目的探讨糖化血红蛋白(HbA1c)、C肽(C-P)水平与2型糖尿病周围神经病变的关联性。方法回顾性分析2020年2月至2022年1月济南市第二人民医院行冠脉造影检查结果诊断为2型糖尿病患者96例(单纯2型糖尿病26例、2型糖尿病周围神经病变70例),另选取32例健康者为健康组。单纯2型糖尿病组男12例、女14例,年龄32~68(55.26±7.14)岁;2型糖尿病周围神经病变组男32例、女38例,年龄30~67(53.24±7.14)岁;健康组男20例、女12例,年龄30~76(58.25±7.69)岁。收集并比较患者临床资料;测定HbA1c、C-P水平;采用Spearman法分析HbA1c、C-P水平与2型糖尿病周围神经病变的相关性。计量资料采用t检验、F检验,计数资料采用χ^(2)检验。结果单纯2型糖尿病组、2型糖尿病周围神经病变组患者HbA1c水平[(7.37±0.87)%、(8.52±0.96)%]、C-P水平[(5.63±1.67)μg/L、(7.14±1.84)μg/L]均高于健康组[(7.02±0.68)%、(3.12±1.53)μg/L],差异均有统计学意义(均P<0.05)。两组2型糖尿病患者性别、年龄、体质量、病程、高血压、吸烟、饮酒、空腹血糖、心率等一般资料比较,差异均无统计学意义(均P>0.05)。Spearman相关性分析结果显示,C-P、HbA1c与2型糖尿病周围神经病变呈正相关(r=0.895、0.870,P=0.010、0.016)。结论2型糖尿病周围神经病变患者HbA1c、C-P水平异常,HbA1c、C-P水平与2型糖尿病周围神经病变相关,可为指导临床早期诊断2型糖尿病周围神经病变并及早进行防治提供一定参考。

Objective To investigate the correlations between the levels of glycosylated hemoglobin(HbA1c)and C-peptide(C-P)and type 2 diabetic peripheral neuropathy.Methods From February 2020 to January 2022,96 patients with type 2 diabetes were diagnosed by coronary angiography in Jinan Second People's Hospital,including 26 cases of simple type 2 diabetes and 70 cases of type 2 diabetic peripheral neuropathy.Another 32 healthy people were selected as the healthy group.In the simple type 2 diabetes group,there were 12 males and 14 females,aged 32-68(55.26±7.14)years;in the type 2 diabetic peripheral neuropathy group,there were 32 males and 38 females,aged 30-67(53.24±7.14)years;in the healthy group,there were 20 males and 12 females,aged 30-76(58.25±7.69)years.The patients'clinical data were collected and compared.The levels of HbA1c and C-P were determined.Spearman method was used to analyze the correlations between HbA1c and C-P levels and type 2 diabetic peripheral neuropathy.t test and F test were used for the measurement data andχ^(2) test for the count data.Results The levels of HbA1c[(7.37±0.87)%and(8.52±0.96)%]and C-P[(5.63±1.67)μg/L and(7.14±1.84)μg/L]in the type 2 diabetes group and the type 2 diabetic peripheral neuropathy group were higher than those in the healthy group[(7.02±0.68)%and(3.12±1.53)μg/L],with statistically significant differences(both P<0.05).There were no statistically significant differences in the general data such as gender,age,body weight,course of disease,hypertension,smoking,drinking,fasting blood glucose,and heart rate between the two groups of type 2 diabetic patients(all P>0.05).Spearman correlation analysis showed that C-P and HbA1c levels were positively correlated with type 2 diabetic peripheral neuropathy(r=0.895,0.870;P=0.010,0.016).Conclusions The levels of HbA1c and C-P are abnormal in patients with type 2 diabetic peripheral neuropathy.The levels of HbA1c and C-P are related to type 2 diabetic peripheral neuropathy,which can provide some references for guiding clinical early diagnosis and early prevention and treatment of type 2 diabetic peripheral neuropathy.