高龄单采血小板献血者血常规参数变化分析

Changes of blood routine parameters in elderly apheresis platelet donors

目的 分析高龄单采血小板献血者自首次献血以来血常规及血小板相关参数的变化,以保障高龄献血者健康和血小板质量。方法 本中心2019~2021年间,年龄达到55~60周岁的单采血小板献血者共计69人,其自首次献血以来共计3 400人次,回顾分析其在55周岁前后血常规及血小板相关参数变化趋势,用单因素方差分析进行组间比较,并进行血小板参数的Pearson相关性分析。结果 同年龄段血常规以及血小板相关参数值男性均高于女性(P<0.05),女性组55岁后血常规中RBC、WBC、Hb、Hct相比55周岁前有下降(P<0.05);55岁后血小板参数中PDW、MPV、PLCR相比55周岁前有升高(P<0.05);而女性55周岁前后Plt相比无统计学差异(P>0.05)。男性组55岁后血常规中WBC相较55周岁前有所下降(P<0.05),55岁后RBC、Hb、Hct相较55周岁前无统计学差异(P>0.05);55岁后血小板相关参数Plt、PDW、MPV、PLCR相比55周岁前有升高(P<0.05)。PDW、MPV和P-LCR变化一致,呈线性正相关。结论 高龄单采血小板献血者血常规检测均在正常范围内且比例相对稳定,可在工作中为高龄献血者定制个性化的献血方案,实施献血者健康管理。

Objective To analyze the changes of blood routine and platelet related parameters of the elderly apheresis platelet donors since the first donation, so as to ensure the health and platelet quality of the elderly apheresis donors. Methods From 2019 to 2021, a total of 69 apheresis platelet donors in our center, aged 55-60 years old, involving 3400 occasions of donation, were enrolled in this study. The change trends of blood routine and platelet related parameters before and after the age of 55 were retrospectively analyzed. One way ANOVA was used for group comparison, and Pearson correlation analysis of platelet parameters was performed. Results The values of blood routine and platelet related parameters were higher in men than in women(P<0.05) when stratified by ages. As for the females in comparison of the parameters before 55 years old, RBC, WBC, Hb and Hct after 55 years old decreased significantly(P<0.05), while the platelet parameters of PDW, MPV and P-LCR elevated(P<0.05), and Plt remained unchanged(P>0.05). As for the males in comparison of the parameters before 55 years old, WBC decreased significantly after 55 years of age(P<0.05), while the platelet parameters of PLT, PDW, MPV and P-LCR elevated(P<0.05), and RBC, Hb and Hct remained with no statistical differences(P>0.05). The changes of PDW, MPV and P-LCR were consistent and showed a linear positive correlation.Conclusion The blood routine tests of the elderly apheresis platelet donors were all within the normal range and the proportion was relatively stable. Personalized blood donation schemes should be customized for the elderly blood donors and the health management of blood donors should be implemented.