脓毒症早期生物诊断标志物研究进展

Research progress on early diagnostic biomarkers for sepsis

脓毒症是因感染引起宿主反应失调导致的危及生命的器官功能障碍,其病情发展迅速、死亡率高。血培养是诊断脓毒症的金标准,但耗时较长。因此,特异性的辅助检查指标成为临床医生诊断脓毒症所关注的焦点。现出现各类脓毒症早期生物诊断标志物,对临床诊断治疗、判断病情预后以及疗效评估具有重要的临床价值。本研究对脓毒症早期生物诊断标志物的研究进展进行综述,为临床早期诊断和治疗脓毒症提供新依据。

Sepsis is a dysregulated host response caused by infection,resulting in a life-threatening organ dysfunctional disease with rapid progression and high mortality.Blood culture is the gold standard for its diagnosis,but it is time-consuming.Therefore,specific auxiliary diagnosis markers have become the focus of clinicians’ attention in diagnosing sepsis.Various types of early biologic diagnostic markers for sepsis are now available,which are of great clinical values for clinical diagnosis and treatment of sepsis,prognosis of the disease and evaluation of efficacy.This study reviews the research progress on early diagnostic biomarkers for sepsis,with a view to providing new evidence for the early clinical diagnosis and treatment of sepsis.