乳腺癌患者治疗前糖化血红蛋白与血清血脂的相关性分析

Correlation Analysis of Serum Lipid Levels and Glycated Hemoglobin A1c before Treatment in Breast Cancer Patients

目的探讨乳腺癌患者治疗前血清糖化血红蛋白与血脂的相关性。方法选取2020年3月至2022年2月就诊于我院且确诊为乳腺癌的患者96例为研究组,另选取同期乳腺良性疾病患者92例为对照组。比较两组血清HbA1c、TG、TC、LDL-C、HDL-C水平;运用ROC分析血清HbA1c、TG、TC、LDL-C、HDL-C水平对乳腺癌的预测价值;比较不同分型乳腺癌患者血清HbA1c、TG、TC、LDL-C、HDL-C水平;采用Spearman相关分析治疗前乳腺癌患者HbA1c与TG、TC、LDL-C、HDL-C的相关性。结果与对照组相比,研究组HbA1c、TG、TC、LDL-C水平均较高,HDL-C水平较低(P<0.05)。ROC分析结果显示血清HbA1c、TG、TC、LDL-C、HDL-C的AUC值分别为0.755、0.935、0.648、0.764、0.795。按乳腺癌病理分型分为4组,各组患者HbA1c、TG、TC、LDL-C、HDL-C水平差异显著(P<0.05)。治疗前乳腺癌患者HbA1c与TG、TC、LDL-C呈正相关,与HDL-C水平呈负相关(P<0.05)。结论血清HbA1c、TG、TC、LDL-C、HDL-C对乳腺癌有一定的预测价值,乳腺癌患者的HbA1c水平可在一定程度上反应其血脂水平。

Objective To investigate the correlation between serum glycosylated hemoglobin and blood lipids in patients with breast cancer before treatment.Methods A total of 96 patients diagnosed with breast cancer in our hospital from March 2020 to February 2022 were selected as the research group,and 92 patients with benign breast diseases in the same period were selected as the control group.The serum levels of HbA1c,TG,TC,LDL-C and HDL-C were compared between the two groups.ROC was used to analyze the predictive value of serum HbA1c,TG,TC,LDL-C and HDL-C levels in breast cancer.The serum levels of HbA1c,TG,TC,LDL-C and HDL-C in patients with different types of breast cancer were compared.Spearman correlation analysis was used to analyze the correlation between HbA1c and TG,TC,LDL-C and HDL-C in breast cancer patients before treatment.Results Compared with the control group,the levels of HbA1c,TG,TC and LDL-C in the study group were higher,and the levels of HDL-C were lower,and the differences were statistically significant(P<0.05).ROC analysis showed that the AUC values of serum HbA1c,TG,TC,LDL-C and HDL-C were 0.755,0.935,0.648,0.764 and 0.795,respectively.According to the pathological type of breast cancer,the patients were divided into 4 groups,and the levels of HbA1c,TG,TC,LDL-C and HDL-C were significantly different among the groups(P<0.05).Before treatment,HbA1c was positively correlated with TG,TC,LDL-C,and negatively correlated with HDL-C(P<0.05).Conclusion Serum HbA1c,TG,TC,LDL-C and HDL-C have certain predictive value for breast cancer.The level of HbA1c in breast cancer patients can reflect the level of blood lipid to a certain extent.