左西孟旦在重症心脏瓣膜病术后的应用价值研究

Clinical Value of Levosimendan in Patients with Severe Heart Valve Disease after Operation

目的分析左西孟旦在重症心脏瓣膜术后的应用效果。方法选取2018年7月至2021年9月在我院接受心脏瓣膜置换术的100例重症心脏瓣膜病患者进行对比研究。根据术后是否使用左西孟旦,将患者分为治疗组(n=58)和对照组(n=52)。对照组术后常规使用β受体阻滞剂、ARB、硝酸酯类、利尿药、强心药等药物。治疗组在此基础上加入左西孟旦注射液,比较两组患者的治疗效果。结果治疗组患者经7天的治疗,平均每小时尿量、左心室射血分数(LVEF)、每搏量(SV)高于对照组,BNP、PCWP水平低于对照组,组间差异有统计学意义(P<0.05)。两组患者的平均引流量比较差异无统计学意义(P>0.05);治疗组患者的中心静脉压和术后住院时间均低于对照组,组间差异有统计学意义(P<0.05)。治疗组不良反应发生率6.90%,低于对照组的17.31%,组间差异有统计学意义(P<0.05)。结论在重症心脏瓣膜病患者心脏瓣膜置换术后使用左西孟旦,能够帮助患者顺利度过术后初期的恢复阶段,值得临床借鉴。

Objective The application effect of levosimendan after severe heart valve surgery was analyzed.Methods 100 patients with severe heart valve disease who underwent heart valve replacement in our hospital from July 2018 to September 2021 were selected for comparative study.Patients were divided into treatment group(n=58)and control group(n=52)according to whether levosimendan was used after operation.The control group was used routinely after operationβReceptor blockers,ARBs,nitrates,diuretics,cardiotonics and other drugs.On this basis,levosimendan injection was added to the treatment group,and the therapeutic effects of the two groups were compared.Results After 7 days of treatment,the average hourly urine volume,left ventricular ejection fraction(LVEF)and stroke volume(SV)in the treatment group were higher than those in the control group,and the levels of BNP and PCWP were lower than those in the control group.The difference between the groups was statistically significant(P<0.05).There was no significant difference in mean drainage volume between the two groups(P>0.05);The central venous pressure and postoperative hospital stay in the treatment group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the treatment group was 6.90%,lower than 17.31%in the control group.There was significant difference between the two groups(P<0.05).Conclusion The use of levosimendan after heart valve replacement in patients with severe heart valvular disease can help patients to successfully pass through the initial postoperative recovery stage,which is worthy of clinical reference.