肠道淋巴细胞归巢与自身免疫性葡萄膜炎的相关性探讨

Intestinal lymphocyte homing and autoimmune uveitis

葡萄膜炎是由眼组织特异性T细胞介导的自身免疫性疾病。肠道菌群激活的眼组织特异性T细胞已被证实可引发小鼠葡萄膜炎,肠道淋巴细胞归巢是其中的关键环节。循环系统中的T淋巴细胞通过表面归巢受体整合素α4β7与其配体黏膜地址素细胞粘附分子-1(MAdCAM-1)特异性识别结合后进入到肠道,再被激活为活化的眼组织特异性T细胞,随后这些眼组织特异性T细胞从肠道不断迁移到眼部,穿越血视网膜屏障进入眼内,引发葡萄膜炎。因此,肠道淋巴细胞归巢在自身免疫性葡萄膜炎的发生发展中可能起重要作用。

Uveitis is an autoimmune disease mediated by eye tissue-specific T cells.Eye tissue-specific T cells activated by the intestinal flora have been confirmed to cause uveitis in mice model,and intestinal lymphocyte homing plays an important role.Circulating T lymphocytes specifically recognize and bind its ligand mucosal addressin adhesion molecule-1(MAdCAM-1)through the surface homing receptorα4β7,enter the intestines and are activated into activated eye tissue-specific T cells.These cells then continue to migrate from the intestine to the eye,cross the blood-retinal barrier and enter the eye,causing uveitis.Therefore,intestinal lymphocyte homing might play an important role in the pathogenesis and development of diseases.