仿生光(电)催化NADH再生

Bioinspired Photo/(Electro)-Catalytic NADH Regeneration

NADH依赖的氧化还原酶广泛应用于精细化学品合成和手性药物开发等领域。NADH作为还原当量在氧化还原酶催化过程中起着关键作用。鉴于高成本NADH的计量性使用,寻求绿色、经济和高效的NADH再生策略是该领域的研究热点和难点。近年来,光(电)催化NADH再生受到了广泛的关注。本文从模拟自然界光合作用的Z机制出发,基于光(电)催化辅酶再生过程中的光诱导电子转移、空穴捕获等关键问题,总结了NADH再生领域的相关工作,为进一步设计高效的辅酶再生体系提供了研究思路。本文最后还简介了NADH依赖的光-酶协同催化的研究进展,并对仿生光催化辅酶再生体系面临的挑战和光-酶偶联的发前景展进行了讨论与展望。

Coenzyme NADH-dependent oxidoreductases are widely used in the fields of fine chemical synthesis and chiral drug development. As a reducing equivalent, NADH plays a key role in oxidoreductase catalysis. In view of the stoichiometric consumption and high cost of NADH, the search for green, feasible and efficient coenzyme regeneration strategies is an important but challenging task. In recent years, photo/(electro)-catalytic method for NADH regeneration has received extensive attention. In this paper, starting from the Z-scheme reaction that simulates natural photosynthesis, based on the photo-induced electron transfer and hole capture in the process of photo/(electro)-catalytic coenzyme regeneration, some recent works related to NADH regeneration are reviewed. The review is expected to provide ideas for further design of efficient coenzyme regeneration system. In addition, the research progress on NADH-dependent photo-enzyme synergistic catalysis in recent years is also briefly introduced, and an outlook is tentatively attempted about the challenges of the biomimetic photocatalytic coenzyme regeneration system and the future developments of photo-enzyme coupling system.