从铁死亡角度试析溃疡性结肠炎湿热病机

Discussion on Pathogenesis of Ulcerative Colitis with"Damp-Heat Syndrome"from Perspective of Ferroptosis

湿热是溃疡性结肠炎的主要病机,而铁死亡与溃疡性结肠炎之间存在着密切联系,铁死亡参与溃疡性结肠炎的发生发展。黄芩汤、香连丸等体现湿热内蕴的中药方剂治疗溃疡性结肠炎小鼠效果显著,具有抗氧化应激作用,同时可影响环氧酶-2(cyclooxygenase-2,COX-2)、长链脂酰辅酶A合成酶4(long-chain acyl-CoA synthetase 4,ACSL4)、谷胱甘肽过氧化物酶4(glutathione peroxidase 4,GPX4)、铁蛋白重链(ferritin heavy chain 1,FTH1)、肿瘤蛋白53(Tumor Protein 53,P53)等铁死亡相关指标的表达,推测黄芩汤作用于溃疡性结肠炎的机制与抑制铁死亡相关,而清热利湿之法将会对溃疡性结肠炎铁死亡产生影响。今后可通过建立动物、细胞实验模型,以黄芩汤进行干预,以期从铁死亡的角度进一步丰富中医“湿热”的科学内涵。

It is believed that Damp-Heat is the main pathogenesis of ulcerative colitis.There is a close relationship between ferrozosis and ulcerative colitis,and ferrozosis is involved in the occurrence and development of ulcerative colitis.Traditional Chinese medicine formulas,such as Huangqin Decoction and Xianglian Pill,that embody the connotation of Damp-Heat have remarkable effects in treating mice with ulcerative colitis,and have antioxidant stress effects,affecting cyclooxygenase-2(COX-2),long-chain acyl-CoA synthetase 4(ACSL4),glutathione peroxidase 4(GPX4),ferritin heavy chain(FTH1,FTH1),tumor protein 53(P53)and other iron-dead related indexes.Therefore,it is speculated that the mechanism of Huangqin Decoction on ulcerative colitis is related to inhibition of ferrozosis,and the method of clearing Damp-Heat would have an impact on ferrozosis in ulcerative colitis.In the future,the experimental model of animals and cells can be established,and Huangqin Decoction can be used in medication,in order to further enrich the scientific connotation of"Damp-Heat"in Chinese medicine from perspective of ferrozosis.