儿童肺炎支原体感染及反复呼吸道感染的危险因素分析

Mycoplasma pneumoniae infection and recurrent respiratory tract infection in children

目的分析儿童肺炎支原体(MP)感染及反复呼吸道感染(RRTI)的危险因素,为临床早期干预提供参考。方法选取辽宁省人民医院2018年1月到2020年1月期间收治的RRTI患儿648例,采用半定量法检测血清MP抗体水平,根据患儿是否合并支原体感染分为实验组(MP阳性,n=283)和对照组(MP阴性,n=365),收集两组患儿年龄、性别、身体质量指数、营养素缺乏、是否早产、贫血、发病季节、集体生活、有无抗菌药物应用等情况,采用logistic回归分析RRTI患儿MP感染的独立危险因素。结果648例RRTI患儿中MP感染患儿283例(43.67%),两组患儿不同年龄和性别儿童肺炎MP感染相比较,差异无统计学意义(P>0.05);两组患儿在营养素缺乏、发病季节、住院时间、发热天数、集体生活、抗菌药物应用间差异具有统计学意义(P<0.05)。logistic回归分析结果表明发病季节、住院时间、集体生活和抗菌药物应用是RRTI患儿MP感染的独立危险因素(P<0.05)。结论RRTI患儿发生MP感染的风险较高,主要危险因素为发病季节、住院时间、集体生活和抗菌药物应用。

Objective To analyze the risk factors of mycoplasma pneumoniae(MP)infection and recurrent respiratory tract infection(RRTI)in children,and to provide reference for early clinical intervention.Methods A total of 648 RRTI children admitted to our hospital from October 2018 to December 2020 were selected.Serum MP antibody levels were detected by semi-quantitative method.According to whether the children were combined with mycoplasma infection,they were divided into experimental group(MP positive,n=283)and control group(MP negative,n=365).Age,gender,body mass index,nutrient deficiency,preterm birth,anemia,onset season,collective living,antibiotics application were collected from the two groups.Logistic regression was used to analyze the independent risk factors of MP infection in RRTI children.Results Among of 648 RRTI children,283(43.67%)had MP infection.There was no statistical significance in MP infection of pneumonia in children of different ages and genders between the two groups(P>0.05).There were statistically significant differences between the two groups in nutrient deficiency,onset season,length of hospital stay,days of fever,group living,application of antibiotics and invasive operation(P<0.05).Logistic regression analysis showed that the onset season,length of hospital stay,group living were independent risk factors for MP infection in RRTI children(P<0.05).Conclusion The risk of MP infection in RRTI children is higher,and the main risk factors are onset season,length of hospital stay,group living and application of antibiotics.