Rh缺失型D-杂合子致新生儿溶血病的血型血清学检测及家系调查

Blood Group Serological Detection and Family Investigation of Hemolytic Disease of the Newborn Caused by Rh Deletion D-heterozygote

目的:对该新生儿及其家系成员进行血型血清学检测,分析新生儿溶血病发生的原因。方法:对患儿进行红细胞系统致新生儿溶血病检测;对患儿母亲进行抗体筛查及抗体鉴定;检测母系家系成员Rh表型并绘制家系图。结果:患儿为Rh缺失型DcE/D-杂合子个体,母亲为Rh缺失型DCe/D-杂合子个体。母亲产生了针对患儿红细胞上Rh血型系统E和c抗原的IgG抗体,引起患儿溶血。该家系中有4位Rh缺失型D-杂合子个体。结论:D-单倍型存在家族遗传性;亲属Rh表型筛查有助于Rh缺失型D-杂合子新生儿溶血病的诊断。

Objective:To conduct blood type serological tests for the newborn and its family members to analyze the causes of neonatal hemolysis.Method:Detection of hemolytic disease of newborn caused by Red Cell Blood group system were performed on this newborn;and antibody screening and antibody identification were carried out for the mothers of the newborn;A pedigree chart was drawn based on the Rh phenotypes of maternal family members.Results:The newborn was a Rh-deficient DcE/D--heterozygote,and the mother was an Rh-deficient DCe/D—heterozygote.The mother produces IgG antibodies against E and c Antigens of Rh blood group system of neonatal erythrocytes,which is the cause of hemolysis of the newborn.Four RH deletion D—heterozygous individuals in this family.Conclusion:D—haploid gene has familial heritable.Rh phenotype screening of relatives is helpful to the diagnosis of RH deletion D—heterozygous neonatal hemolytic disease.