手性共价有机框架合成的研究进展

Research Progress in the Synthesis of Chiral Covalent Organic Frameworks

共价有机框架(COFs)是一类由有机小分子单体通过共价键连接而成的晶型有机多孔材料,具有良好的化学稳定性、规则的孔道和大的比表面积等优点。而手性共价有机框架(CCOFs)在具备以上优势的同时,还因具有特殊的手性环境,在手性分离、手性识别和不对称催化等领域具有广泛的应用。综述了近年来CCOFs的设计原理及合成方法,阐述了该领域仍存在的挑战和未来的机遇。

Covalent organic frameworks(COFs)are a class of crystalline organic porous materials constructed by organic monomers via covalent bonds,which has the advantages of good chemical stability,regular pores,large specific surface areas and so on.In addition to the above advantages and their special chiral environment chiral covalent organic frameworks(CCOFs)have been widely used in chiral separation,chiral recognition,asymmetric catalysis,et al.The design principles and synthesis methods of CCOFs in recent years are summarized,and the remaining challenges and future opportunities in this field are expounded.