负压式鼻腔冲洗治疗儿童急性鼻窦炎的效果观察

Observation on Effect of Negative Pressure Nasal Irrigation in Treatment of Acute Sinusitis in Children

目的:探讨负压式鼻腔冲洗治疗儿童急性鼻窦炎的效果。方法:选取2020年7月-2022年5月和平县妇幼保健院收治的186例急性鼻窦炎患儿为研究对象,根据治疗方法的不同分为对照组和观察组,各93例。对照组采用阿莫西林克拉维酸钾分散片治疗,观察组在对照组基础上加用负压式鼻腔冲洗治疗,对比两组治疗效果。结果:治疗前,两组超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、中性粒细胞比例(N)、白细胞计数(WBC)水平比较,差异无统计学意义(P>0.05);治疗1周后,两组hs-CRP、TNF-α、N、WBC水平均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组视觉模拟评分法(VAS)评分(鼻塞、流涕、咽痛、嗅觉减退)及Lund-Kennedy评分比较,差异无统计学意义(P>0.05);治疗5 d、10 d后,两组VAS评分及Lund-Kennedy评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在急性鼻窦炎患儿治疗中辅以负压式鼻腔冲洗治疗安全有效,且有助于减轻炎性反应,改善临床症状。

Objective:To explore the effect of negative pressure nasal irrigation in the treatment of acute sinusitis in children.Methods:A total of 186 children with acute sinusitis who were treated in Heping County Maternity&Child Health Hospital from July 2020 to May 2022 were selected as the study subjects.According to different treatment methods,the children were divided into control group and observation group,with 93 cases in each group.The control group was treated with amoxicillin and clavulanate potassium dispersible tablets,and the observation group was treated with negative pressure nasal irrigation on the basis of control group.The treatment effects of the two groups were compared.Results:Before treatment,there was no statistically significant difference in the levels of high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),neutrophil ratio(N),and white blood cell count(WBC)between the two groups(P>0.05).After 1 week of treatment,the levels of hs-CRP,TNF-α,N and WBC in two groups were lower than those before treatment,the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in visual analogue score(VAS)score(nasal congestion,runny nose,sore throat,hyposmia)and Lund-Kennedy score between the two groups(P>0.05).After 5 days and 10 days of treatment,the VAS score and Lund-Kennedy score in the two groups were lower than those before treatment,the observation group was lower than the control group,and the difference was statistically significant(P<0.05).The overall effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Negative pressure nasal irrigation is safe and effective in the treatment of children with acute sinusitis,and can help alleviate inflammatory reaction and improve clinical symptoms.