人乳头瘤病毒分型及液基薄层细胞检测在宫颈病变筛查中的价值分析

Analysis on Value of Human Papillomavirus Typing and Thinprep Cytologic Test in Screening of Cervical Lesions

目的:探讨人乳头瘤病毒(HPV)分型及液基薄层细胞检测(TCT)在宫颈病变筛查中的价值。方法:选取2021年3-12月在湖南省人民医院经HPV筛查阳性的1 430例患者为研究对象,并统计其中行TCT的1 238例患者HPV分型的感染情况,并从细胞学水平对宫颈病变程度进行分析。结果:HPV亚型单一感染814例,多重感染616例。最常见的低危型为6、11型,高危型为52、58、16型。不同年龄段TCT结果比较,差异有统计学意义(P<0.05)。宫颈高级别病变患者均为高危型HPV感染,其中50~59岁患者的病变率最高。结论:宫颈高级别病变与高危型HPV感染具有相关性,HPV分型及TCT应用于宫颈病变筛查,有助于宫颈癌的早发现、早治疗,具有较高的临床应用价值。

Objective: To explore the value of human papillomavirus(HPV) typing and Thinprep cytologic test(TCT) in the screening of cervical lesions. Methods: A total of 1430 patients who were screened positive for HPV in Hunan Provincial People’s Hospital from March 2021 to December 2021 were selected as the study subjects. Among them, HPV typing and infection in 1238 patients who underwent TCT examination were summarized, and the degree of cervical lesions was analyzed from cytology level.Results: There were 814 patients with HPV subtype single infection and 616 patients with HPV subtype multiple infections. The most common low-risk HPV were HPV6 and HPV11. The most common high-risk HPV were HPV52, HPV58 and HPV16. There were significant differences in TCT results at different ages(P<0.05). Patients with high-grade cervical lesions were high-risk HPV infection, and the highest rate of lesions was at the age of 50-59 years old. Conclusion: The high-grade cervical lesions are associated with high-risk HPV infection. HPV typing combined with TCT in cervical lesion screening is conducive to early detection and early treatment of cervical cancer, and has high clinical application value.