摘要
目的探讨HLA-Cw^(*)0602和LCE3BLCE3C-del基因交互作用对内蒙古地区蒙古族人群寻常型银屑病发病风险的影响。方法选取内蒙古医科大学附属医院2006年1月至2015年12月诊治的蒙古族寻常型银屑病患者365例(病例组)及同期健康体检者284例(对照组)。经过性别、年龄匹配和质量控制后,应用SPSS 20.0软件分析HLA-Cw^(*)0602和LCE3BLCE3C-del等位基因分别与蒙古族寻常型银屑病人群的关联性;应用logistic回归分析两等位基因交互作用(校正包括年龄、性别在内的潜在混杂因素)。结果通过对HLA-Cw^(*)0602与LCE3CLCE3B-del等位基因进行交互作用分析发现,显性遗传模式HLA-Cw^(*)0602等位基因与隐性遗传模式LCE3CLCE3B-del等位基因logistic回归交互项Int结果示OR=2.38,P=0.033,且交互作用指数S=1.21,表明两者效应增强具有协同作用。结论HLA-Cw^(*)0602和LCE3BLCE3C-del同时存在可能增加内蒙古地区蒙古族人群寻常型银屑病的发病风险。
Objective To investigate the effect of HLA-Cw^(*)0602 and LCE3B_LCE3C-del allele interaction on the risk of psoriasis vulgaris in a population of Mongolian nationality in Inner Mongolia.Methods A total of 365 Mongolian patients with psoriasis vulgaris who received treatment in The Affiliated Hospital of Inner Mongolia Medical University from January 2006 to December 2015(case group)and 284 healthy subjects who concurrently received physical examination in the same hospital(control group)were included in this study.After sex and age matching,and quality control,the correlations between HLA-Cw^(*)0602 and LCE3B_LCE3C-del allele and psoriasis vulgaris in a population of Mongolian nationality were analyzed using SPSS 20.0 software.The interaction between HLA-Cw^(*)0602 and LCE3B_LCE3C-del alleles(adjusting for potential confounders including age and sex)was analyzed using logistic regression.Results Logistic regression interaction item Int of dominant inheritance mode HLA-Cw^(*)0602 allele and recessive inheritance mode LCE3C_LCE3B-del allele revealed OR=2.38,P=0.033,and interaction index S=1.21,indicating that there was a synergistic effect between the two alleles.Conclusion The co-existence of HLA-Cw^(*)0602 and LCE3B_LCE3C-del may increase the risk of psoriasis vulgaris in a population of Mongolian nationality in Inner Mongolia.
作者
田利民
李利仲
曹玉婷
赵文超
孙立
Tian Limin;Li Lizhong;Cao Yuting;Zhao Wenchao;Sun Li(Department of Dermatology,The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,Inner Mongolia Autonomous Region,China;Department of Dermatology,Qingshuihe Maternal and Child Health Hospital,Hohhot 011600,Inner Mongolia Autonomous Region,China;Department of Dermatology,Inner Mongolia Maternity and Child Health Care Hospital,Hohhot 010050,Inner Mongolia Autonomous Region,China;Department of Apheresis,Blood Center of Inner Mongolia Autonomous Region,Hohhot 010050,Inner Mongolia Autonomous Region,China;Department of Dermatology,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia Autonomous Region,China)
出处
《中国基层医药》
CAS
2022年第12期1818-1821,共4页
Chinese Journal of Primary Medicine and Pharmacy
