人胎盘片联合活性叶酸多种维生素片对先兆流产保胎患者Th1细胞因子及激素水平的影响

Effects of human placenta tablets combined with active folic acid and compound nutrient tablets on Th1 cytokines and hormone levels in pregnant patients with threatened miscarriage

目的探讨人胎盘片联合活性叶酸多种维生素片对先兆流产保胎患者Th1细胞因子及激素水平的影响。方法选取临沂市中医医院2021年4-9月诊治的先兆流产保胎患者226例为观察对象,采用随机数字表法分为两组各113例。对照组采用人胎盘片治疗,观察组采用人胎盘片联合活性叶酸多种维生素片治疗,两组均治疗4周。比较两组治疗前后Th1细胞因子、β-人绒毛膜促性腺激素(β-hCG)、孕酮(P)、雌二醇(E_(2))水平,以及保胎成功率、不良反应及围生期并发症发生情况。结果治疗4周后,观察组白细胞介素2、肿瘤坏死因子α及干扰素γ水平均低于对照组(t=27.53、20.99、31.69,均P<0.001);观察组β-hCG、P、E_(2)分别为(143.79±9.56)IU/L、(36.43±4.71)ng/L、(234.72±13.29)pmol/L,均高于对照组的(122.53±7.47)IU/L、(29.32±4.22)ng/L、(167.86±8.93)pmol/L(t=18.63、11.95、44.39,均P<0.001);观察组保胎成功率为92.9%,高于对照组的76.1%,差异有统计学意义(χ^(2)=12.20,P<0.05);两组不良反应发生率、围生期并发症发生率差异均无统计学意义(均P>0.05)。结论人胎盘片联合活性叶酸多种维生素片能改善先兆流产保胎患者Th1细胞因子及激素水平,提高保胎成功率,且联合使用未增加不良反应及围生期并发症发生率。

Objective To investigate the effects of human placenta tablets combined with active folic acid and compound nutrient tablets on Th1 cytokines and hormone levels in pregnant patients with threatened miscarriage.Methods A total of 226 pregnant patients with threatened miscarriage who received treatment in Linyi Traditional Chinese Medicine Hospital from April to September 2021 were included in this study.They were randomly divided into a control group and an observation group,with 113 patients in each group.The control group was treated with human placenta tablets.The observation group was treated with human placenta tablets combined with active folic acid and compound nutrient tablets.All patients were treated for 4 weeks.Before and after treatment,serum levels of Th1 cytokines,β-human chorionic gonadotropin,progesterone,and estradiol as well as the rate of success of protection against miscarriage,adverse reactions,and perinatal complications were compared between the two groups.Results After 4 weeks of treatment,serum levels of interleukin-2,tumor necrosis factor-α,and interferon-γin the observation group were significantly lower than those in the control group(t=27.53,20.99,31.69,all P<0.001).Serum levels ofβ-human chorionic gonadotropin,progesterone,and estradiol in the observation group were(143.79±9.56)IU/L,(36.43±4.71)ng/L,(234.72±13.29)pmol/L,which were significantly higher than(122.53±7.47)IU/L,(29.32±4.22)ng/L,(167.86±8.93)pmol/L in the control group(t=18.63,11.95,44.39,all P<0.001).The rate of success of protection against miscarriage in the observation group was significantly higher than that in the control group(92.9%vs.76.1%,χ^(2)=12.20,P<0.05).There were no significant differences in the incidences of adverse reactions and perinatal compilations between the two groups(both P>0.05).Conclusion Human placenta tablets combined with active folic acid and compound nutrient tablets can improve serum levels of Th1 cytokines and hormones,and increase the rate of success of protection against miscarriage,without increasing the incidences of adverse reactions and perinatal complications.