糖皮质激素联合特布他林雾化治疗慢阻肺急性加重期患者的疗效及对炎症因子、肺功能的影响

Effect of Glucocorticoid Combined with Terbutaline Atomization on Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and its Effect on Inflammatory Factors and Lung Function

目的研究糖皮质激素联合特布他林雾化治疗慢阻肺急性加重期患者的疗效及对患者炎症因子、肺功能的影响。方法选取2020年1月-12月入院接受治疗的慢阻肺急性加重期患者68例,按照随机数字表法分为研究组和对照组,各34例,对照组采用特布他林雾化治疗,研究组采用糖皮质激素联合特布他林雾化治疗,比较两组临床疗效、炎症因子水平[白细胞介素-6(IL-6)、C-反应蛋白(CRP)]、肺功能[第1 s用力肺活量(FEV_(1))、用力肺活量(FVC)、最大呼气中段流量(MMEF)、呼气峰流速(PEF)]、血气功能[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、动脉血氧饱和度(SaO_(2))]及临床症状消退时间。结果研究组总有效率为97.06%,高于对照组的76.47%,差异有统计学意义(P<0.05);研究组治疗后IL-6、CRP水平低于对照组,差异有统计学意义(P<0.05);研究组治疗后FEV_(1)、FVC、MMEF、PEF均优于对照组,差异有统计学意义(P<0.05);研究组治疗后PaO_(2)、PaCO_(2)、SaO_(2)均优于对照组,差异有统计学意义(P<0.05);研究组喘息缓解时间、咳嗽消失时间、哮鸣音基本消失时间均低于对照组,差异有统计学意义(P<0.05)。结论采用糖皮质激素联合特布他林雾化治疗慢阻肺急性加重期患者的总有效率更高,同时,有利于缓解患者机体炎症反应,加快肺功能和血气功能恢复,缩短临床症状缓解时间,具有较高的临床应用价值。

Objective To study the efficacy of glucocorticoid combined with terbutaline atomization in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease and its effect on inflammatory factors and lung function.Methods A total of 68 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to hospital from January to December 2020 were selected and divided into study group and control group according to the random number table method,with 34 cases in each group.The control group was treated with terbutaline atomization,and the study group was treated with glucocorticoid combined with terbutaline atomization.The clinical efficacy,levels of inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP)],pulmonary function[forced vital capacity in the first second(FEV_(1)),forced vital capacity(FVC),maximum mid-expiratory flow(MMEF),peak expiratory flow rate(PEF)],blood gas function[partial pressure of arterial oxygen(PaO_(2)),partial pressure of arterial carbon dioxide(PaCO_(2)),arterial oxygen saturation(SaO_(2))]and clinical symptom regression time were compared between the two groups.Results The total effective rate of the study group was 97.06%,which was higher than 76.47%of the control group,and the difference was statistically significant(P<0.05).The levels of IL-6 and CRP in the study group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).FEV_(1),FVC,MMEF and PEF in the study group after treatment were better than those in the control group,and the differences were statistically significant(P<0.05).PaO_(2),PaCO_(2) and SaO_(2) in the study group after treatment were better than those in the control group,and the differences were statistically significant(P<0.05).The wheezing remission time,cough disappearance time and wheezing sound disappearance time in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion The total effective rate of glucocorticoid combined with terbutaline atomization in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease is higher.At the same time,it is beneficial to alleviate the inflammatory response of patients,accelerate the recovery of lung function and blood gas function,and shorten the remission time of clinical symptoms.It has high clinical application value.