补肾调周法在围绝经期综合症中的应用效果

Application effect of Invigorating Kidney and Regulating Menstruation in Perimenopausal Syndrome

目的观察补肾调周法治疗围绝经期综合症的临床效果。方法选取2020年1月-2021年6月在我院诊治的72例围绝经期综合症患者为研究对象,采用随机数字表法分为对照组和观察组,各36例。对照组给予常规激素治疗,观察组在对照组基础上联合补肾调周法治疗,比较两组临床疗效、性激素水平、月经周期、月经经期、中医证候评分及不良反应发生率。结果观察组治疗总有效率为94.44%,高于对照组的83.33%(P<0.05);两组血清雌二醇(E_(2))水平均高于治疗前,促卵泡刺激素(FSH)、促黄体生成素(LH)均低于治疗前,且观察组E_(2)高于对照组,FSH、LH低于对照组(P<0.05);观察组月经周期、月经经期均大于对照组(P<0.05);观察组月经紊乱、心烦易怒、头晕头痛、腰膝酸软、失眠多梦、胁痛口苦、阴部干涩各症状评分均低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论补肾调周法治疗围绝经期综合症效果确切,可减轻患者中医证候症状,改善性激素水平,促进月经周期、月经经期的恢复,且不会增加不良反应。

Objective To observe the clinical effect of invigorating kidney and regulating menstruation on perimenopausal syndrome.Methods A total of 72 patients with perimenopausal syndrome who were treated in our hospital from January 2020 to June 2021 were selected as the study subjects.They were divided into a control group and an observation group by random number table method,with 36 cases in each group.The control group was treated with conventional hormone therapy,and the observation group was treated with invigorating kidney and regulating menstruation therapy on the basis of the control group.The clinical efficacy,sex hormone level,menstrual cycle,menstrual period,TCM syndrome score and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.44%,which was higher than 83.33%of the control group(P<0.05).The levels of serum estradiol(E_(2))in the two groups were higher than those before treatment,and the levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH)were lower than those before treatment,while the level of E_(2) in the observation group was higher than that in the control group,and the levels of FSH and LH were lower than those in the control group(P<0.05).The menstrual cycle and menstrual period of the observation group were greater than those of the control group(P<0.05).The scores of menstrual disorder,irritability,dizziness and headache,soreness and weakness of waist and knees,insomnia and dreaminess,hypochondriac pain,bitter taste in the mouth,and vaginal dryness in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The method of invigorating kidney and regulating menstruation is effective in the treatment of perimenopausal syndrome,which can reduce the symptoms of TCM syndromes,improve the level of sex hormones,promote the recovery of menstrual cycle and menstrual period,and will not increase adverse reactions.