复方嗜酸乳杆菌片、四磨汤、多潘立酮联合治疗小儿消化不良的临床效果

Clinical effect of compound Eosinophil-Lactobacillus tablets, Simo decoction and domperidone in combined treatment of pediatric indigestion

目的 探讨复方嗜酸乳杆菌片、四磨汤、多潘立酮联合治疗小儿消化不良的临床效果。方法 选取2018年1月至2020年12月我院接收的110例小儿消化不良患儿,根据随机抽签法将其分为参照组和试验组,各55例。参照组实施四磨汤联合多潘立酮治疗,试验组在参照组基础上联合复方嗜酸乳杆菌片治疗。比较两组的治疗效果。结果 试验组的恶心呕吐、烧心、反酸、食欲减退、腹胀腹痛持续时间均短于参照组,差异具有统计学意义(P<0.05)。治疗前,两组的胃动素、P物质水平比较,差异无统计学意义(P>0.05);治疗后,试验组的胃动素、P物质水平高于参照组,差异具有统计学意义(P<0.05)。试验组的治疗总有效率高于参照组,差异具有统计学意义(P<0.05)。试验组的不良反应总发生率低于参照组,差异具有统计学意义(P<0.05)。治疗前,两组的胃窦收缩频率、胃窦收缩幅度比较,差异无统计学意义(P>0.05);治疗后,试验组的胃窦收缩频率、胃窦收缩幅度高于参照组,差异具有统计学意义(P<0.05)。结论 复方嗜酸乳杆菌片、四磨汤、多潘立酮联合治疗小儿消化不良的效果显著,能够快速缓解患儿的临床症状,且安全性高。

Objective To explore of clinical effects of compound Eosinophil-Lactobacillus tablets, Simo decoction and domperidone in combined treatment of pediatric indigestion. Methods A total of 110 children with pediatric indigestion received in our hospital from January 2018 to December 2020 were selected and divided into reference group and experimental group according to random lottery method, with 55 cases in each group. The reference group was treated with Simo decoction combined with domperidone, and the experimental group was treated with compound Eosinophil-Lactobacillus tablets on the basis of the control group. The therapeutic effects of the two groups were compared. Results The duration of nausea and vomiting, heartburn, acid reflux, loss of appetite, abdominal distension and abdominal pain in the experimental group were shorter than those in the reference group, and the differences were statistically significant(P <0.05). Before treatment, there were no significant differences in the levels of motilin and substance P between the two groups(P>0.05);after treatment, the levels of motilin and substance P in the experimental group were higher than those in the reference group, and the differences were statistically significant(P<0.05). The total effective rate of treatment in the experimental group was higher than that in the reference group, and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the experimental group was lower than that in the reference group, and the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in the gastric antrum contraction frequency and gastric antrum contraction amplitude between the two groups(P>0.05);after treatment, the gastric antrum contraction frequency and gastric antrum contraction amplitude in the experimental group were higher than those in the reference group, and the differences were statistically significant(P <0.05). Conclusion Compound Eosinophil-Lactobacillus tablets, Simo decoction and domperidone in combined treatment of pediatric indigestion has remarkable effect, it can quickly relieve the clinical symptoms of children, with high safety.