解脲支原体感染对不同年龄段IVF/ICSI-ET/FET患者妊娠结局的影响

Effects of ureaplasma urealyticum infection on pregnancy outcomes in IVF/ICSI-ET/FET patients of different ages

目的:探究解脲支原体感染对不同年龄段体外受精/卵胞浆内单精子显微注射-胚胎移植/冻胚解冻移植(IVF/ICSI-ET/FET)患者妊娠结局的影响。方法:收集2014年10月~2020年10月在弋矶山医院生殖医学中心接受IVF/ICSI-ET/FET助孕的887例(周期)不孕患者的相关资料进行回顾性分析,20~34岁为低龄组,35~46岁为高龄组;根据其助孕前支原体检查结果分为A组(阳性组)、B组(阳性治疗后转阴组)、C组(阴性组),采用方差齐性检验、LSD-t检验、卡方检验或Fisher确切概率法分析得出不同年龄阶段的相关资料及检查结果和患者妊娠结局的关系。结果:低龄组3组临床妊娠率差异无统计学意义(P>0.05);A组和C组的分娩率均高于B组(P<0.05),而A组和C组的分娩率差异无统计学意义(P>0.05);高龄组B组和C组的临床妊娠率均高于A组(P<0.05),而B组和C组的分娩率差异无统计学意义(P>0.05);C组的分娩率高于A组(P<0.05),而其他组间的分娩率差异无统计学意义(P>0.05)。结论:高龄组支原体阳性的不孕患者临床妊娠率和分娩率显著降低,提示感染支原体可能会对高龄女性的IVF/ICSI-ET/FET助孕结局产生不利影响。

Objective:To investigate the effects of ureaplasma urealyticum infection on pregnancy outcomes in women of different ages undergone in-vitro fertilization/intracytoplasmic sperm injection and embryo transfer/freezing and thawing embryo transfer(IVF/ICSI-ET/FET).Methods:The related data were collected from 887 women undergone IVF/ICSI-ET/FET in the reproductive center of our hospital between October 2014 and 2020,and retrospectively analyzed.All cases were initially allocated to younger age group(20-34 years)and older age group(35-46 years),and then divided into group A(positive group),group B(conversion from positive to negative after treatment)and group C(negative group)according to the tested results of mycoplasma before IVF/ICSI-ET/FET.The homogeneity test of variance,LSD-t test,Chi-square test or Fisher′s exact probability method were used to analyze relevant data and test results in different ages of women to examine the relationship between these findings and the pregnancy outcomes.Results:There was no significant difference in the clinical pregnancy rate among the three sub-groups in the younger women(P>0.05),yet the delivery rate of group A and C was higher than that of group B,with statistical significance(P<0.05).No significant difference was seen between group A and group C regarding the delivery rate(P>0.05).In the older group,women in group B and C had higher clinical pregnancy rate than those in group A(P<0.05),whereas there was no significant difference in delivery rate between group B and group C(P>0.05).Although women in group C had higher delivery rate than those in group A(P<0.05),yet the difference was insignificant among other groups(P>0.05).Conclusion:The clinical pregnancy rate and delivery rate were significantly lower in infertility women of older age with positive mycoplasma,which suggests that mycoplasma infection may adversely affect the pregnancy outcomes assisted by IVF/ICSI-ET/FET.